Yoo Hyun Um1,2, Tae-Won Kim1,2, Jong-Hyun Jeong1, Ho-Jun Seo1, Jin-Hee Han1, Sung-Min Kim1,2, Ji Hyun Song2, Seung-Chul Hong1,2. 1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 2. Sleep Disorders Clinic, Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
Abstract
STUDY OBJECTIVES: Narcolepsy is a chronic disorder with numerous adverse long-term consequences including increased obesity, high mortality rates, and decreased quality of life. With emerging attention to the long-term course of the disorder and importance of accurate diagnosis, the diagnostic stability of the Multiple Sleep Latency Test (MSLT)-the mostly frequently used test to identify narcolepsy-is often challenged. METHODS: In this study, we compared the baseline and follow-up demographic characteristics and body mass index (BMI) of patients with narcolepsy type 1. Moreover, MSLT results from repeated tests conducted on 48 patients with narcolepsy type 1 were compared, with mean follow-up of approximately 10 years. RESULTS: BMI from the baseline to the follow-up visit was significantly increased in the participants. There were no significantly different parameter changes in MSLT results. CONCLUSIONS: MSLT has good test-retest validity in patients with narcolepsy type 1. Close surveillance for the detection and management of obesity is warranted in clinical settings.
STUDY OBJECTIVES:Narcolepsy is a chronic disorder with numerous adverse long-term consequences including increased obesity, high mortality rates, and decreased quality of life. With emerging attention to the long-term course of the disorder and importance of accurate diagnosis, the diagnostic stability of the Multiple Sleep Latency Test (MSLT)-the mostly frequently used test to identify narcolepsy-is often challenged. METHODS: In this study, we compared the baseline and follow-up demographic characteristics and body mass index (BMI) of patients with narcolepsy type 1. Moreover, MSLT results from repeated tests conducted on 48 patients with narcolepsy type 1 were compared, with mean follow-up of approximately 10 years. RESULTS: BMI from the baseline to the follow-up visit was significantly increased in the participants. There were no significantly different parameter changes in MSLT results. CONCLUSIONS: MSLT has good test-retest validity in patients with narcolepsy type 1. Close surveillance for the detection and management of obesity is warranted in clinical settings.
Authors: M Folkerts; L Rosenthal; T Roehrs; S Krstevska; A Murlidhar; F Zorick; R Wittig; T Roth Journal: Biol Psychiatry Date: 1996-08-01 Impact factor: 13.382
Authors: Petra Kovalská; David Kemlink; Eva Topinková; Soňa Nevšímalová; Eszter Maurovich Horvat; Karel Šonka Journal: Sleep Med Date: 2016-11-24 Impact factor: 3.492
Authors: Ute Kretzschmar; Esther Werth; Christian Sturzenegger; Ramin Khatami; Claudio L Bassetti; Christian R Baumann Journal: J Sleep Res Date: 2016-02-10 Impact factor: 3.981
Authors: Claire E H M Donjacour; N Ahmad Aziz; Sebastiaan Overeem; Andries Kalsbeek; Hanno Pijl; Gert Jan Lammers Journal: Sleep Date: 2014-04-01 Impact factor: 5.849