Huiling Liu1, Bin Liu2, Chunxia Gao1, Bin Meng3, Huilin Yang1,4, Haiyang Yu2, Lei Yang5,6. 1. Department of Orthopaedics and Orthopaedics Institute, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China. 2. Department of Orthopaedics, Fuyang People' s Hospital, Fuyang, Anhui, 236000, People's Republic of China. 3. Department of Orthopaedics and Orthopaedics Institute, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China. mbyang2000@126.com. 4. International Research Center for Translational Orthopaedics (IRCTO) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China. 5. Department of Orthopaedics and Orthopaedics Institute, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China. leiy@suda.edu.cn. 6. International Research Center for Translational Orthopaedics (IRCTO) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China. leiy@suda.edu.cn.
Abstract
PURPOSE: Poly(methyl methacrylate) (PMMA) cement is widely used for percutaneous kyphoplasty and vertebroplasty (PKP and PVP) but possesses formidable shortcomings due to non-degradability. Here, a biodegradable replacement is developed. METHODS: Calcium phosphate cement (CPC) was redesigned by incorporating starch and BaSO4 (new cement named as CPB). The biomechanical, biocompatibility, osseointegrative and handling properties of CPB were systematically evaluated in vitro and in vivo by the models of osteoporotic sheep vertebra, rat subcutaneous implantation and rat femoral defect. RESULTS: CPB revealed appropriate injectability and setting ability for PKP and PVP. More importantly, its biomechanical strengths measured by in vitro and in vivo models were not less than that of PMMA, while its biodegradability and osseointegrative capacities were significantly enhanced compared to PMMA. CONCLUSIONS: CPB is injectable, biomechanically robust, biodegradable and osseointegrative, demonstrating revolutionary potential for the application in PKP and PVP.
PURPOSE:Poly(methyl methacrylate) (PMMA) cement is widely used for percutaneous kyphoplasty and vertebroplasty (PKP and PVP) but possesses formidable shortcomings due to non-degradability. Here, a biodegradable replacement is developed. METHODS:Calcium phosphate cement (CPC) was redesigned by incorporating starch and BaSO4 (new cement named as CPB). The biomechanical, biocompatibility, osseointegrative and handling properties of CPB were systematically evaluated in vitro and in vivo by the models of osteoporotic sheep vertebra, rat subcutaneous implantation and rat femoral defect. RESULTS:CPB revealed appropriate injectability and setting ability for PKP and PVP. More importantly, its biomechanical strengths measured by in vitro and in vivo models were not less than that of PMMA, while its biodegradability and osseointegrative capacities were significantly enhanced compared to PMMA. CONCLUSIONS:CPB is injectable, biomechanically robust, biodegradable and osseointegrative, demonstrating revolutionary potential for the application in PKP and PVP.
Authors: Ioannis N Gaitanis; Alexander G Hadjipavlou; Pavlos G Katonis; Michael N Tzermiadianos; Dritan S Pasku; Avinash G Patwardhan Journal: Eur Spine J Date: 2004-10-08 Impact factor: 3.134
Authors: Pengyan Qiao; Juan Wang; Qiufei Xie; Fangfang Li; Limin Dong; Tao Xu Journal: Mater Sci Eng C Mater Biol Appl Date: 2013-07-24 Impact factor: 7.328
Authors: Seiji Tomita; Sean Molloy; Louis E Jasper; Muneaki Abe; Stephen M Belkoff Journal: Spine (Phila Pa 1976) Date: 2004-06-01 Impact factor: 3.468