Literature DB >> 29111229

The Academic-Industrial Complexity: Failure to Launch.

Leonard A Levin1, Francine Behar-Cohen2.   

Abstract

The pharmaceutical industry has long known that ∼80% of the results of academic laboratories cannot be reproduced when repeated in industry laboratories. Yet academic investigators are typically unaware of this problem, which severely impedes the drug development process. This academic-industrial complication is not one of deception, but rather a complex issue related to how scientific research is carried out and translated in strikingly different enterprises. This Opinion describes the reasons for inconsistencies between academic and industrial laboratories and what can be done to repair this failure of translation.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  bench to bedside; drug development; translational failure

Mesh：

Year:  2017        PMID： 29111229      PMCID： PMC5696093          DOI： 10.1016/j.tips.2017.10.003

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  21 in total

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Authors:  Kevin Mullane; Michael Williams
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Review 4.  Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely".

Authors:  M M Smith; E C Clarke; C B Little
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5.  Scientific method: statistical errors.

Authors:  Regina Nuzzo
Journal:  Nature       Date:  2014-02-13       Impact factor: 49.962

6.  An incentive-based approach for improving data reproducibility.

Authors:  Michael Rosenblatt
Journal:  Sci Transl Med       Date:  2016-04-27       Impact factor: 17.956

Review 7.  What does research reproducibility mean?

Authors:  Steven N Goodman; Daniele Fanelli; John P A Ioannidis
Journal:  Sci Transl Med       Date:  2016-06-01       Impact factor: 17.956

8.  SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Authors:  Michelle Pacholec; John E Bleasdale; Boris Chrunyk; David Cunningham; Declan Flynn; Robert S Garofalo; David Griffith; Matt Griffor; Pat Loulakis; Brandon Pabst; Xiayang Qiu; Brian Stockman; Venkataraman Thanabal; Alison Varghese; Jessica Ward; Jane Withka; Kay Ahn
Journal:  J Biol Chem       Date:  2010-01-08       Impact factor: 5.157

9.  Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

Authors:  Gemma Llovera; Kerstin Hofmann; Stefan Roth; Angelica Salas-Pérdomo; Maura Ferrer-Ferrer; Carlo Perego; Elisa R Zanier; Uta Mamrak; Andre Rex; Hélène Party; Véronique Agin; Claudine Fauchon; Cyrille Orset; Benoît Haelewyn; Maria-Grazia De Simoni; Ulrich Dirnagl; Ulrike Grittner; Anna M Planas; Nikolaus Plesnila; Denis Vivien; Arthur Liesz
Journal:  Sci Transl Med       Date:  2015-08-05       Impact factor: 17.956

10.  Why most published research findings are false.

Authors:  John P A Ioannidis
Journal:  PLoS Med       Date:  2005-08-30       Impact factor: 11.613
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  5 in total

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Journal:  Trends Pharmacol Sci       Date:  2021-06-27       Impact factor: 17.638

2.  Darkness in the Human Gene and Protein Function Space: Widely Modest or Absent Illumination by the Life Science Literature and the Trend for Fewer Protein Function Discoveries Since 2000.

Authors:  Swati Sinha; Birgit Eisenhaber; Lars Juhl Jensen; Bharata Kalbuaji; Frank Eisenhaber
Journal:  Proteomics       Date:  2018-10-30       Impact factor: 3.984

Review 3.  On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook.

Authors:  Carolina Montoya; Yu Du; Anthony L Gianforcaro; Santiago Orrego; Maobin Yang; Peter I Lelkes
Journal:  Bone Res       Date:  2021-02-11       Impact factor: 13.567

4.  Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma.

Authors:  Michal Geva; Noga Gershoni-Emek; Luana Naia; Philip Ly; Sandra Mota; Ana Cristina Rego; Michael R Hayden; Leonard A Levin
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Review 5.  Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future.

Authors:  Leonard A Levin; Christopher Patrick; Nozhat B Choudry; Najam A Sharif; Jeffrey L Goldberg
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  5 in total

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