Literature DB >> 34187693

Bridging the academia-to-industry gap: organ-on-a-chip platforms for safety and toxicology assessment.

Terry Ching1, Yi-Chin Toh2, Michinao Hashimoto3, Yu Shrike Zhang4.   

Abstract

Some organ-on-a-chip (OoC) systems for drug evaluation show better predictive capabilities than planar, static cell cultures and animal models. One of the ongoing initiatives led by OoC developers is to bridge the academia-to-industry gap in the hope of gaining wider adoption by end-users - academic biological researchers and industry. We discuss several recommendations that can help to drive the adoption of OoC systems by the market. We first review some key challenges faced by OoC developers before highlighting current advances in OoC platforms. We then offer recommendations for OoC developers to promote the uptake of OoC systems by the industry.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID: 34187693      PMCID: PMC8364498          DOI: 10.1016/j.tips.2021.05.007

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN: 0165-6147            Impact factor:   17.638


  80 in total

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2.  Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

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Journal:  Exp Biol Med (Maywood)       Date:  2017-06-16

3.  Advances in organ-, body-, and disease-on-a-chip systems.

Authors:  Michael L Shuler
Journal:  Lab Chip       Date:  2018-12-18       Impact factor: 6.799

Review 4.  In silico models in drug development: where we are.

Authors:  Janet Piñero; Laura I Furlong; Ferran Sanz
Journal:  Curr Opin Pharmacol       Date:  2018-09-08       Impact factor: 5.547

Review 5.  Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.

Authors:  Ying I Wang; Carlos Carmona; James J Hickman; Michael L Shuler
Journal:  Adv Healthc Mater       Date:  2017-12-04       Impact factor: 9.933

6.  Prototype pathogen approach for pandemic preparedness: world on fire.

Authors:  Barney S Graham; Kizzmekia S Corbett
Journal:  J Clin Invest       Date:  2020-07-01       Impact factor: 14.808

7.  Robotic fluidic coupling and interrogation of multiple vascularized organ chips.

Authors:  Richard Novak; Debarun Das; Anna Herland; Ben M Maoz; Mahadevabharath R Somayaji; Rachelle Prantil-Baun; Miles Ingram; Susan Marquez; Aaron Delahanty; Sauveur S F Jeanty; Morgan Burt; Elizabeth Calamari; Angeliki Chalkiadaki; Alexander Cho; Youngjae Choe; David Benson Chou; Michael Cronce; Stephanie Dauth; Toni Divic; Jose Fernandez-Alcon; Thomas Ferrante; John Ferrier; Edward A FitzGerald; Rachel Fleming; Sasan Jalili-Firoozinezhad; Thomas Grevesse; Josue A Goss; Tiama Hamkins-Indik; Olivier Henry; Chris Hinojosa; Tessa Huffstater; Kyung-Jin Jang; Ville Kujala; Lian Leng; Robert Mannix; Yuka Milton; Janna Nawroth; Bret A Nestor; Carlos F Ng; Blakely O'Connor; Tae-Eun Park; Henry Sanchez; Josiah Sliz; Alexandra Sontheimer-Phelps; Ben Swenor; Guy Thompson; George J Touloumes; Zachary Tranchemontagne; Norman Wen; Moran Yadid; Anthony Bahinski; Geraldine A Hamilton; Daniel Levner; Oren Levy; Andrzej Przekwas; Kevin K Parker; Donald E Ingber
Journal:  Nat Biomed Eng       Date:  2020-01-27       Impact factor: 25.671

8.  Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro.

Authors:  Vincent van Duinen; Wendy Stam; Viola Borgdorff; Arie Reijerkerk; Valeria Orlova; Paul Vulto; Thomas Hankemeier; Anton Jan van Zonneveld
Journal:  J Vis Exp       Date:  2019-11-06       Impact factor: 1.355

9.  Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips.

Authors:  Kimberly A Homan; David B Kolesky; Mark A Skylar-Scott; Jessica Herrmann; Humphrey Obuobi; Annie Moisan; Jennifer A Lewis
Journal:  Sci Rep       Date:  2016-10-11       Impact factor: 4.379

10.  Trends in FDA drug approvals over last 2 decades: An observational study.

Authors:  Angelika Batta; Bhupinder Singh Kalra; Raj Khirasaria
Journal:  J Family Med Prim Care       Date:  2020-01-28
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  5 in total

1.  A Facile Method for Generating a Smooth and Tubular Vessel Lumen Using a Viscous Fingering Pattern in a Microfluidic Device.

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Journal:  Front Bioeng Biotechnol       Date:  2022-05-02

2.  Fourier light-field imaging of human organoids with a hybrid point-spread function.

Authors:  Wenhao Liu; Ge-Ah R Kim; Shuichi Takayama; Shu Jia
Journal:  Biosens Bioelectron       Date:  2022-03-26       Impact factor: 12.545

Review 3.  Emerging microfluidics-enabled platforms for osteoarthritis management: from benchtop to bedside.

Authors:  Zhou Zou; Xiaohe Luo; Zhengkun Chen; Yu Shrike Zhang; Chunyi Wen
Journal:  Theranostics       Date:  2022-01-01       Impact factor: 11.600

4.  Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips.

Authors:  Aisen Vivas; Albert van den Berg; Robert Passier; Mathieu Odijk; Andries D van der Meer
Journal:  Lab Chip       Date:  2022-03-15       Impact factor: 6.799

Review 5.  Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system.

Authors:  Chutong Tian; Shunzhe Zheng; Xinying Liu; Ken-Ichiro Kamei
Journal:  J Nanobiotechnology       Date:  2022-07-20       Impact factor: 9.429

  5 in total

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