Literature DB >> 29110759

The Expanding Role of APOL1 Risk in Chronic Kidney Disease and Cardiovascular Disease.

Michelle M Estrella1, Rulan S Parekh2.   

Abstract

Variants of the APOL1 gene, found primarily in individuals of African descent, are associated with various forms of kidney disease and kidney disease progression. Recent studies evaluating the association of APOL1 with cardiovascular disease have yielded conflicting results, and the potential role in cardiovascular disease remains unclear. In this review, we summarize the observational studies linking the APOL1 risk variants with chronic kidney and cardiovascular disease among persons of African descent.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  APOL1; Health disparities; chronic kidney disease; genetic testing

Mesh：

Substances：

Year:  2017        PMID： 29110759     DOI： 10.1016/j.semnephrol.2017.07.005

Source DB:  PubMed          Journal:  Semin Nephrol        ISSN： 0270-9295            Impact factor:   5.299


  5 in total

1.  Beyond Panel-Based Testing: Exome Analysis Increases Sensitivity for Diagnosis of Genetic Kidney Disease.

Authors:  Parker C Wilson; Latisha Love-Gregory; Meagan Corliss; Samantha McNulty; Jonathan W Heusel; Joseph P Gaut
Journal:  Kidney360       Date:  2020-05-13

Review 2.  Apolipoprotein L1 nephropathies: 2017 in review.

Authors:  Jeffrey B Kopp; Hila Roshanravan; Koji Okamoto
Journal:  Curr Opin Nephrol Hypertens       Date:  2018-05       Impact factor: 2.894

Review 3.  Genetics, Genomics, and Precision Medicine in End-Stage Kidney Disease.

Authors:  Jeffrey B Kopp; Cheryl A Winkler
Journal:  Semin Nephrol       Date:  2018-07       Impact factor: 5.299

4.  Racial disparities in end-stage renal disease in a high-risk population: the Southern Community Cohort Study.

Authors:  Fabian Bock; Thomas G Stewart; Cassianne Robinson-Cohen; Jennifer Morse; Edmond K Kabagambe; Kerri L Cavanaugh; Kelly A Birdwell; Adriana M Hung; Khaled Abdel-Kader; Edward D Siew; Elvis A Akwo; William J Blot; T Alp Ikizler; Loren Lipworth
Journal:  BMC Nephrol       Date:  2019-08-07       Impact factor: 2.388

5.  Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.

Authors:  Archna Bajaj; Andrea Ihegword; Chengxiang Qiu; Aeron M Small; Wei-Qi Wei; Lisa Bastarache; QiPing Feng; Rachel L Kember; Marjorie Risman; Roy D Bloom; David L Birtwell; Heather Williams; Christian M Shaffer; Jinbo Chen; Regeneron Genetics Center; Joshua C Denny; Daniel J Rader; C Michael Stein; Scott M Damrauer; Katalin Susztak
Journal:  Kidney Int       Date:  2020-02-17       Impact factor: 10.612
  5 in total

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