Richard Dirven1, Ardalan Ebrahimi2, Nikolaus Moeckelmann3, Carsten Erich Palme4, Ruta Gupta5, Jonathan Clark6. 1. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia. Electronic address: dirvenrichard@hotmail.com. 2. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia; Department of Head & Neck Surgery, Liverpool Hospital, Sydney, Australia; Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Sydney, Australia. 3. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia. 4. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia; Central Clinical School, University of Sydney, Sydney, Australia. 5. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia; Central Clinical School, University of Sydney, Sydney, Australia; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia. 6. Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia; Central Clinical School, University of Sydney, Sydney, Australia; South West Clinical School, University of New South Wales, Sydney, Australia.
Abstract
OBJECTIVES: The primary aim of this study is to compare the effect of using tumor thickness versus depth of invasion (DOI) to determine the 8th edition AJCC T-category on survival in a large cohort of OSCC. MATERIALS AND METHODS: A retrospective cohort study of patients whose clinicopathologic information had been collected prospectively into a dedicated head and neck database. 927 patients with oral SCC were identified in this cohort, with the final study population including 456 patients with complete information on DOI, tumor thickness, T and N staging and follow-up. RESULTS: 26 (5.7%) patients had a different AJCC 8 T category when using thickness instead of depth. 15 were upstaged from T1 to T2, 10 upstaged from T2 to T3 and 1 down staged from T2 to T1. Additionally, similar stratification of disease-specific and overall survival curves were found for T category based on DOI and thickness. CONCLUSION: The T category and TNM stage prognostic performance of 8th edition AJCC staging of oral cancer is similar regardless of whether DOI or thickness is used as the T-category modifier. In centers without complete DOI data it is reasonable to impute thickness for retrospective survival analyses using the 8th edition of the AJCC staging system.
OBJECTIVES: The primary aim of this study is to compare the effect of using tumor thickness versus depth of invasion (DOI) to determine the 8th edition AJCC T-category on survival in a large cohort of OSCC. MATERIALS AND METHODS: A retrospective cohort study of patients whose clinicopathologic information had been collected prospectively into a dedicated head and neck database. 927 patients with oral SCC were identified in this cohort, with the final study population including 456 patients with complete information on DOI, tumor thickness, T and N staging and follow-up. RESULTS: 26 (5.7%) patients had a different AJCC 8 T category when using thickness instead of depth. 15 were upstaged from T1 to T2, 10 upstaged from T2 to T3 and 1 down staged from T2 to T1. Additionally, similar stratification of disease-specific and overall survival curves were found for T category based on DOI and thickness. CONCLUSION: The T category and TNM stage prognostic performance of 8th edition AJCC staging of oral cancer is similar regardless of whether DOI or thickness is used as the T-category modifier. In centers without complete DOI data it is reasonable to impute thickness for retrospective survival analyses using the 8th edition of the AJCC staging system.
Authors: Alexander Ross Kerr; Michael E Robinson; Cyril Meyerowitz; Douglas E Morse; Maria L Aguilar; Scott L Tomar; Lisa Guerrero; Dianne Caprio; Linda M Kaste; Sonia K Makhija; Rahma Mungia; Linda Rasubala; Walter J Psoter Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2020-05-23
Authors: Alhadi Almangush; Antti A Mäkitie; Laura K Mäkinen; Joonas H Kauppila; Matti Pukkila; Jaana Hagström; Jussi Laranne; Ylermi Soini; Luiz Paulo Kowalski; Reidar Grénman; Caj Haglund; Ricardo D Coletta; Tuula Salo; Ilmo Leivo Journal: Virchows Arch Date: 2018-07-23 Impact factor: 4.064