Literature DB >> 2910207

Anaphylactic symptoms due to chlorhexidine gluconate.

M Okano1, M Nomura, S Hata, N Okada, K Sato, Y Kitano, M Tashiro, Y Yoshimoto, R Hama, T Aoki.   

Abstract

Six patients who developed urticaria, dyspnea, and anaphylactic shock due to topical application of chlorhexidine gluconate solution are described. Chlorhexidine gluconate was confirmed as the causative agent of type I hypersensitivity by intradermal, scratch, and epicutaneous tests. To prevent life-threatening adverse reactions, it seems important to use chlorhexidine gluconate on wound surfaces at a concentration of 0.05%, as recommended by the manufacturer; chlorhexidine gluconate may not be suitable for application to mucous membranes.

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Year:  1989        PMID： 2910207

Source DB:  PubMed          Journal:  Arch Dermatol        ISSN： 0003-987X


  17 in total

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