Literature DB >> 29092928

The ISB Cancer Genomics Cloud: A Flexible Cloud-Based Platform for Cancer Genomics Research.

Sheila M Reynolds1, Michael Miller2, Phyliss Lee2, Kalle Leinonen2, Suzanne M Paquette2, Zack Rodebaugh2, Abigail Hahn2, David L Gibbs2, Joseph Slagel2, William J Longabaugh2, Varsha Dhankani2, Madelyn Reyes3, Todd Pihl3, Mark Backus3, Matthew Bookman4,5, Nicole Deflaux4,5, Jonathan Bingham4,5, David Pot3, Ilya Shmulevich1.   

Abstract

The ISB Cancer Genomics Cloud (ISB-CGC) is one of three pilot projects funded by the National Cancer Institute to explore new approaches to computing on large cancer datasets in a cloud environment. With a focus on Data as a Service, the ISB-CGC offers multiple avenues for accessing and analyzing The Cancer Genome Atlas, TARGET, and other important references such as GENCODE and COSMIC using the Google Cloud Platform. The open approach allows researchers to choose approaches best suited to the task at hand: from analyzing terabytes of data using complex workflows to developing new analysis methods in common languages such as Python, R, and SQL; to using an interactive web application to create synthetic patient cohorts and to explore the wealth of available genomic data. Links to resources and documentation can be found at www.isb-cgc.org Cancer Res; 77(21); e7-10. ©2017 AACR. ©2017 American Association for Cancer Research.

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Year:  2017        PMID: 29092928      PMCID: PMC5780183          DOI: 10.1158/0008-5472.CAN-17-0617

Source DB:  PubMed          Journal:  Cancer Res        ISSN: 0008-5472            Impact factor:   12.701


  11 in total

1.  Kaviar: an accessible system for testing SNV novelty.

Authors:  Gustavo Glusman; Juan Caballero; Denise E Mauldin; Leroy Hood; Jared C Roach
Journal:  Bioinformatics       Date:  2011-09-28       Impact factor: 6.937

Review 2.  Dialogue on reverse-engineering assessment and methods: the DREAM of high-throughput pathway inference.

Authors:  Gustavo Stolovitzky; Don Monroe; Andrea Califano
Journal:  Ann N Y Acad Sci       Date:  2007-10-09       Impact factor: 5.691

3.  The Sequence Alignment/Map format and SAMtools.

Authors:  Heng Li; Bob Handsaker; Alec Wysoker; Tim Fennell; Jue Ruan; Nils Homer; Gabor Marth; Goncalo Abecasis; Richard Durbin
Journal:  Bioinformatics       Date:  2009-06-08       Impact factor: 6.937

4.  GENCODE: the reference human genome annotation for The ENCODE Project.

Authors:  Jennifer Harrow; Adam Frankish; Jose M Gonzalez; Electra Tapanari; Mark Diekhans; Felix Kokocinski; Bronwen L Aken; Daniel Barrell; Amonida Zadissa; Stephen Searle; If Barnes; Alexandra Bignell; Veronika Boychenko; Toby Hunt; Mike Kay; Gaurab Mukherjee; Jeena Rajan; Gloria Despacio-Reyes; Gary Saunders; Charles Steward; Rachel Harte; Michael Lin; Cédric Howald; Andrea Tanzer; Thomas Derrien; Jacqueline Chrast; Nathalie Walters; Suganthi Balasubramanian; Baikang Pei; Michael Tress; Jose Manuel Rodriguez; Iakes Ezkurdia; Jeltje van Baren; Michael Brent; David Haussler; Manolis Kellis; Alfonso Valencia; Alexandre Reymond; Mark Gerstein; Roderic Guigó; Tim J Hubbard
Journal:  Genome Res       Date:  2012-09       Impact factor: 9.043

5.  Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.

Authors:  Helga Thorvaldsdóttir; James T Robinson; Jill P Mesirov
Journal:  Brief Bioinform       Date:  2012-04-19       Impact factor: 11.622

Review 6.  The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge.

Authors:  Katarzyna Tomczak; Patrycja Czerwińska; Maciej Wiznerowicz
Journal:  Contemp Oncol (Pozn)       Date:  2015

7.  A cloud-based workflow to quantify transcript-expression levels in public cancer compendia.

Authors:  P J Tatlow; Stephen R Piccolo
Journal:  Sci Rep       Date:  2016-12-16       Impact factor: 4.379

8.  COSMIC: somatic cancer genetics at high-resolution.

Authors:  Simon A Forbes; David Beare; Harry Boutselakis; Sally Bamford; Nidhi Bindal; John Tate; Charlotte G Cole; Sari Ward; Elisabeth Dawson; Laura Ponting; Raymund Stefancsik; Bhavana Harsha; Chai Yin Kok; Mingming Jia; Harry Jubb; Zbyslaw Sondka; Sam Thompson; Tisham De; Peter J Campbell
Journal:  Nucleic Acids Res       Date:  2016-11-28       Impact factor: 16.971

9.  miRBase: annotating high confidence microRNAs using deep sequencing data.

Authors:  Ana Kozomara; Sam Griffiths-Jones
Journal:  Nucleic Acids Res       Date:  2013-11-25       Impact factor: 16.971

10.  Ensembl Genomes 2016: more genomes, more complexity.

Authors:  Paul Julian Kersey; James E Allen; Irina Armean; Sanjay Boddu; Bruce J Bolt; Denise Carvalho-Silva; Mikkel Christensen; Paul Davis; Lee J Falin; Christoph Grabmueller; Jay Humphrey; Arnaud Kerhornou; Julia Khobova; Naveen K Aranganathan; Nicholas Langridge; Ernesto Lowy; Mark D McDowall; Uma Maheswari; Michael Nuhn; Chuang Kee Ong; Bert Overduin; Michael Paulini; Helder Pedro; Emily Perry; Giulietta Spudich; Electra Tapanari; Brandon Walts; Gareth Williams; Marcela Tello-Ruiz; Joshua Stein; Sharon Wei; Doreen Ware; Daniel M Bolser; Kevin L Howe; Eugene Kulesha; Daniel Lawson; Gareth Maslen; Daniel M Staines
Journal:  Nucleic Acids Res       Date:  2015-11-17       Impact factor: 16.971

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  18 in total

Review 1.  Progress Toward Cancer Data Ecosystems.

Authors:  Robert L Grossman
Journal:  Cancer J       Date:  2018 May/Jun       Impact factor: 3.360

2.  Building a Science Gateway For Processing and Modeling Sequencing Data Via Apache Airavata.

Authors:  Zhong Wang; Marcus A Christie; Eroma Abeysinghe; Tinyi Chu; Suresh Marru; Marlon Pierce; Charles G Danko
Journal:  Pract Exp Adv Res Comput 2018 (2018)       Date:  2018-07

3.  Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer.

Authors:  Hanwen Wang; Chen Zhao; Cesar A Santa-Maria; Leisha A Emens; Aleksander S Popel
Journal:  iScience       Date:  2022-06-30

4.  A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma.

Authors:  Boris Aguilar; David L Gibbs; David J Reiss; Mark McConnell; Samuel A Danziger; Andrew Dervan; Matthew Trotter; Douglas Bassett; Robert Hershberg; Alexander V Ratushny; Ilya Shmulevich
Journal:  Gigascience       Date:  2020-07-01       Impact factor: 6.524

5.  Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis.

Authors:  SungHee Park; Mattia Brugiolo; Martin Akerman; Shipra Das; Laura Urbanski; Adam Geier; Anil K Kesarwani; Martin Fan; Nathan Leclair; Kuan-Ting Lin; Leo Hu; Ian Hua; Joshy George; Senthil K Muthuswamy; Adrian R Krainer; Olga Anczuków
Journal:  Cell Rep       Date:  2019-11-26       Impact factor: 9.995

6.  Before and After: Comparison of Legacy and Harmonized TCGA Genomic Data Commons' Data.

Authors:  Galen F Gao; Joel S Parker; Sheila M Reynolds; Tiago C Silva; Liang-Bo Wang; Wanding Zhou; Rehan Akbani; Matthew Bailey; Saianand Balu; Benjamin P Berman; Denise Brooks; Hu Chen; Andrew D Cherniack; John A Demchok; Li Ding; Ina Felau; Sharon Gaheen; Daniela S Gerhard; David I Heiman; Kyle M Hernandez; Katherine A Hoadley; Reyka Jayasinghe; Anab Kemal; Theo A Knijnenburg; Peter W Laird; Michael K A Mensah; Andrew J Mungall; A Gordon Robertson; Hui Shen; Roy Tarnuzzer; Zhining Wang; Matthew Wyczalkowski; Liming Yang; Jean C Zenklusen; Zhenyu Zhang; Han Liang; Michael S Noble
Journal:  Cell Syst       Date:  2019-07-24       Impact factor: 11.091

Review 7.  Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework.

Authors:  Gustavo Glusman; Peter W Rose; Andreas Prlić; Jennifer Dougherty; José M Duarte; Andrew S Hoffman; Geoffrey J Barton; Emøke Bendixen; Timothy Bergquist; Christian Bock; Elizabeth Brunk; Marija Buljan; Stephen K Burley; Binghuang Cai; Hannah Carter; JianJiong Gao; Adam Godzik; Michael Heuer; Michael Hicks; Thomas Hrabe; Rachel Karchin; Julia Koehler Leman; Lydie Lane; David L Masica; Sean D Mooney; John Moult; Gilbert S Omenn; Frances Pearl; Vikas Pejaver; Sheila M Reynolds; Ariel Rokem; Torsten Schwede; Sicheng Song; Hagen Tilgner; Yana Valasatava; Yang Zhang; Eric W Deutsch
Journal:  Genome Med       Date:  2017-12-18       Impact factor: 11.117

8.  Microbiome analyses of blood and tissues suggest cancer diagnostic approach.

Authors:  Gregory D Poore; Evguenia Kopylova; Qiyun Zhu; Carolina Carpenter; Serena Fraraccio; Stephen Wandro; Tomasz Kosciolek; Stefan Janssen; Jessica Metcalf; Se Jin Song; Jad Kanbar; Sandrine Miller-Montgomery; Robert Heaton; Rana Mckay; Sandip Pravin Patel; Austin D Swafford; Rob Knight
Journal:  Nature       Date:  2020-03-11       Impact factor: 49.962

9.  NCI Imaging Data Commons.

Authors:  Andrey Fedorov; William J R Longabaugh; David Pot; David A Clunie; Steve Pieper; Hugo J W L Aerts; André Homeyer; Rob Lewis; Afshin Akbarzadeh; Dennis Bontempi; William Clifford; Markus D Herrmann; Henning Höfener; Igor Octaviano; Chad Osborne; Suzanne Paquette; James Petts; Davide Punzo; Madelyn Reyes; Daniela P Schacherer; Mi Tian; George White; Erik Ziegler; Ilya Shmulevich; Todd Pihl; Ulrike Wagner; Keyvan Farahani; Ron Kikinis
Journal:  Cancer Res       Date:  2021-06-15       Impact factor: 12.701

10.  Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes.

Authors:  Zhuyi Xue; René L Warren; Ewan A Gibb; Daniel MacMillan; Johnathan Wong; Readman Chiu; S Austin Hammond; Chen Yang; Ka Ming Nip; Catherine A Ennis; Abigail Hahn; Sheila Reynolds; Inanc Birol
Journal:  BMC Genomics       Date:  2018-07-13       Impact factor: 3.969

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