Literature DB >> 2909291

Phase II trial of continuous-infusion iproplatin (CHIP) and 5-fluorouracil (5-FU) in advanced colorectal carcinoma.

N J Petrelli1, P J Creaven, L Herrera, A Mittelman.   

Abstract

Following the observation of antitumor activity for the combination of 5-fluorouracil (5-FU) and cisplatin in metastatic colorectal carcinoma, the combination of 5-FU and iproplatin was tested, also in colorectal carcinoma, in the hope of attaining equivalent activity without the nephrotoxicity observed with 5-FU/cisplatin. However, no responses were achieved with 5-FU/iproplatin.

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Year:  1989        PMID: 2909291     DOI: 10.1007/BF00258461

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN: 0344-5704            Impact factor:   3.333


  3 in total

1.  Combination chemotherapy of cisplatin and 5-fluorouracil for advanced colorectal adenocarcinoma.

Authors:  N J Petrelli; S Madejewicz; Y Rustum; L Herrera; P J Creaven; J Plager; J Soloman; A Mittelman
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

2.  Evaluation of the nephrotoxicity of iproplatin (CHIP) in comparison to cisplatin by the measurement of urinary enzymes.

Authors:  L Pendyala; S Madajewicz; S B Lele; S G Arbuck; P J Creaven
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

3.  Phase I clinical trial of cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum(IV) (CHIP).

Authors:  P J Creaven; S Madajewicz; L Pendyala; A Mittelman; E Pontes; M Spaulding; S Arbuck; J Solomon
Journal:  Cancer Treat Rep       Date:  1983-09
  3 in total
  2 in total

Review 1.  The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.

Authors:  Timothy C Johnstone; Kogularamanan Suntharalingam; Stephen J Lippard
Journal:  Chem Rev       Date:  2016-02-11       Impact factor: 60.622

Review 2.  Nanoparticles Loaded with Platinum Drugs for Colorectal Cancer Therapy.

Authors:  Buhle Buyana; Tobeka Naki; Sibusiso Alven; Blessing Atim Aderibigbe
Journal:  Int J Mol Sci       Date:  2022-09-24       Impact factor: 6.208

  2 in total

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