Jie Zhang1, Wenjun Zhou2, Ryan M Cassidy3, Hang Su4, Yindan Su5, Xiangyang Zhang6. 1. Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: drzhangj@yahoo.com. 2. Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. 3. Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA. 4. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5. The Affiliated High School to Hangzhou Normal University, Hangzhou, China. 6. Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA; Beijing HuiLongGuan Hospital, Peking University, Beijing, China. Electronic address: zhangxy9@gmail.com.
Abstract
OBJECTIVE: The goal of this study is to identify risk factors for the presence of amyloid accumulation in the brains of patients reporting subjective cognitive decline (SCD). Identifying such risk factors will help better identify patients who ought to receive neuroimaging studies to confirm plaque presence and begin intervention, as well as enhancing the study of the pathogenesis of Alzheimer's disease. METHODS: Ninety-nine SCD participants (72.2±5.6years, 57.6% female) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) underwent florbetapir PET. Logistic regression analysis was conducted to examine the relationship between the presence of an increased amyloid signal (amyloid positivity) and several potential risk factors, including: demographics, APOE ε4 genotype, family history of dementia, history of hypertension, history of cigarettes smoking, cognitive function and depressive symptoms. RESULTS: Being female was a significant risk factor for amyloid positivity (OR=4.915, 95% CI=1.709-14.139), as was being an APOE ε4 carrier (OR=2.985, 95% CI=1.084-8.219) and having a history of cigarette smoking (OR=4.091, 95% CI=1.483-11.285). CONCLUSION: Our study demonstrates that female gender, APOE ε4 genotype, and history of cigarettes smoking are associated with amyloid positivity in patients with SCD.
OBJECTIVE: The goal of this study is to identify risk factors for the presence of amyloid accumulation in the brains of patients reporting subjective cognitive decline (SCD). Identifying such risk factors will help better identify patients who ought to receive neuroimaging studies to confirm plaque presence and begin intervention, as well as enhancing the study of the pathogenesis of Alzheimer's disease. METHODS: Ninety-nine SCDparticipants (72.2±5.6years, 57.6% female) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) underwent florbetapir PET. Logistic regression analysis was conducted to examine the relationship between the presence of an increased amyloid signal (amyloid positivity) and several potential risk factors, including: demographics, APOE ε4 genotype, family history of dementia, history of hypertension, history of cigarettes smoking, cognitive function and depressive symptoms. RESULTS: Being female was a significant risk factor for amyloid positivity (OR=4.915, 95% CI=1.709-14.139), as was being an APOE ε4 carrier (OR=2.985, 95% CI=1.084-8.219) and having a history of cigarette smoking (OR=4.091, 95% CI=1.483-11.285). CONCLUSION: Our study demonstrates that female gender, APOE ε4 genotype, and history of cigarettes smoking are associated with amyloid positivity in patients with SCD.
Authors: Gonzalo Sánchez-Benavides; Gemma Salvadó; Eider M Arenaza-Urquijo; Oriol Grau-Rivera; Marc Suárez-Calvet; Marta Milà-Alomà; José María González-de-Echávarri; Carolina Minguillon; Marta Crous-Bou; Aida Niñerola-Baizán; Andrés Perissinotti; Juan Domingo Gispert; José Luis Molinuevo Journal: Alzheimers Dement (Amst) Date: 2020-11-11
Authors: G O Reynolds; L Manning; D Kirn; H Klein; O Hampton; O Burke; R Buckley; D Rentz; R Sperling; G A Marshall; R E Amariglio Journal: J Prev Alzheimers Dis Date: 2022