Liqun Sun1,2, Andreas Kaesler3, Piyumindri Fernando1, Alex J Thompson1, John M Toomasian1, Robert H Bartlett1. 1. 1 Surgery, University of Michigan, Ann Arbor, MI, USA. 2. 2 Department of Intensive Medicine, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. 3. 3 Dept. of Cardiovascular Engineering, Institute for Applied Medical Engineering, Aachen, Germany.
Abstract
INTRODUCTION: Commercial membrane lungs are designed to transfer a specific amount of oxygen per unit of venous blood flow. Membrane lungs are much more efficient at removing CO2 than adding oxygen, but the range of CO2 transfer is rarely reported. METHODS: Commercial membrane lungs were studied with the goal of evaluating CO2 removal capacity. CO2 removal was measured in 4 commercial membrane lungs under standardized conditions. CONCLUSION: CO2 clearance can be greater than 4 times that of oxygen at a given blood flow when the gas to blood flow ratio is elevated to 4:1 or 8:1. The CO2 clearance was less dependent on surface area and configuration than oxygen transfer. Any ECMO system can be used for selective CO2 removal.
INTRODUCTION: Commercial membrane lungs are designed to transfer a specific amount of oxygen per unit of venous blood flow. Membrane lungs are much more efficient at removing CO2 than adding oxygen, but the range of CO2 transfer is rarely reported. METHODS: Commercial membrane lungs were studied with the goal of evaluating CO2 removal capacity. CO2 removal was measured in 4 commercial membrane lungs under standardized conditions. CONCLUSION:CO2 clearance can be greater than 4 times that of oxygen at a given blood flow when the gas to blood flow ratio is elevated to 4:1 or 8:1. The CO2 clearance was less dependent on surface area and configuration than oxygen transfer. Any ECMO system can be used for selective CO2 removal.
Entities:
Keywords:
CO2 removal; blood flow; membrane lung; sweep gas flow; sweep gas to blood flow ratio
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