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Literature DB >> 29086181

The B7 Family Member B7-H6: a New Bane of Tumor.

Abstract

B7-H6 is a ligand of NKp30, which is an activating receptor of natural killer (NK) cells. High expression of B7-H6 is found in certain types of tumor cells, such as lymphoma, leukemia and gastric carcinoma. The expression of B7-H6 can be induced by inflammatory stress in healthy cells. The expression of B7-H6 is significantly correlated with distant metastasis status and post-operative prognosis in cancer patients. The effectiveness of B7-H6 modified antitumor immunotherapy strategies had been verified in tumor-bearing mice, which opened a new door to targeted therapy. In this review, we will focus on the recent development on the roles of B7-H6 in tumor immunity, as well as mechanisms involved in the regulation of B7-H6 expression.

Entities: Disease Gene Species

Keywords: B7-H6; NKp30; Tumor immunity

Mesh：

Substances：

Year: 2017 PMID： 29086181 DOI： 10.1007/s12253-017-0357-5

Source DB: PubMed Journal: Pathol Oncol Res ISSN： 1219-4956 Impact factor: 3.201

47 in total

Review 1. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.

Authors: Saverio Minucci; Pier Giuseppe Pelicci
Journal: Nat Rev Cancer Date: 2006-01 Impact factor: 60.716

2. Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies.

Authors: E Wu; P I Croucher; N McKie
Journal: Biochem Biophys Res Commun Date: 1997-06-18 Impact factor: 3.575

3. B7-H6 expression in non-small cell lung cancers.

Authors: Xiuqin Zhang; Guangbo Zhang; Yan Qin; Ruizhen Bai; Jianan Huang
Journal: Int J Clin Exp Pathol Date: 2014-09-15

4. NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor.

Authors: Massimo Vitale; Mariella Della Chiesa; Simona Carlomagno; Daniela Pende; Maurizio Aricò; Lorenzo Moretta; Alessandro Moretta
Journal: Blood Date: 2005-03-22 Impact factor: 22.113

5. Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.

Authors: Tal I Arnon; Hagit Achdout; Ofer Levi; Gal Markel; Nivin Saleh; Gil Katz; Roi Gazit; Tsufit Gonen-Gross; Jacob Hanna; Efrat Nahari; Angel Porgador; Alik Honigman; Bodo Plachter; Dror Mevorach; Dana G Wolf; Ofer Mandelboim
Journal: Nat Immunol Date: 2005-04-10 Impact factor: 25.606

6. Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis.

Authors: S Ohta; M Harigai; M Tanaka; Y Kawaguchi; T Sugiura; K Takagi; C Fukasawa; M Hara; N Kamatani
Journal: J Rheumatol Date: 2001-08 Impact factor: 4.666

7. Increased expression of ADAM family members in human breast cancer and breast cancer cell lines.

Authors: Uwe Lendeckel; Jana Kohl; Marco Arndt; Stacy Carl-McGrath; Hans Donat; Christoph Röcken
Journal: J Cancer Res Clin Oncol Date: 2004-09-30 Impact factor: 4.553

8. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.

Authors: Cameron S Brandt; Myriam Baratin; Eugene C Yi; Jacob Kennedy; Zeren Gao; Brian Fox; Betty Haldeman; Craig D Ostrander; Tomonori Kaifu; Christian Chabannon; Alessandro Moretta; Robert West; Wenfeng Xu; Eric Vivier; Steven D Levin
Journal: J Exp Med Date: 2009-06-15 Impact factor: 14.307

9. Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production.

Authors: Maryam Salimi; Luzheng Xue; Helen Jolin; Clare Hardman; David J Cousins; Andrew N J McKenzie; Graham S Ogg
Journal: J Immunol Date: 2015-11-18 Impact factor: 5.422

10. Clinical significance of B7-H6 protein expression in astrocytoma.

Authors: Jian-Gui Guo; Cheng-Cheng Guo; Zhen-Qiang He; Zhi-Gang Liu; Yang Wang; Yong-Gao Mou
Journal: Onco Targets Ther Date: 2016-05-31 Impact factor: 4.147

16 in total

1. Expression of B7-H6 in chronic myeloid leukemia and its clinical significance.

Authors: Yanglin Cao; Li Huo; Ling Zhou; Jianfeng Yang; Zhen Weng; Xiaofei Yang; Jiannong Cen; Yang He
Journal: Int J Clin Exp Pathol Date: 2019-02-01

2. Sevoflurane impedes glioma progression via regulating circ_0000215/miR-1200/NCR3LG1 axis.

Authors: Zhitao Zhao; Baofeng Gao; Xiaoling Zong; Ruiming Gao
Journal: Metab Brain Dis Date: 2021-08-30 Impact factor: 3.584

3. B7 homolog 6 promotes the progression of cervical cancer.

Authors: Ruimeng Guo; Guoyan Liu; Changying Li; Xuejing Liu; Yanying Xu; Weina Yang; Fang Wang
Journal: Exp Ther Med Date: 2021-05-18 Impact factor: 2.447

Review 4. Immunomodulation of NK Cells by Ionizing Radiation.

Authors: Jiarui Chen; Xingyu Liu; Zihang Zeng; Jiali Li; Yuan Luo; Wenjie Sun; Yan Gong; Junhong Zhang; Qiuji Wu; Conghua Xie
Journal: Front Oncol Date: 2020-06-16 Impact factor: 6.244

5. Key Role of the CD56^lowCD16^low Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells.

Authors: Elisabetta Vulpis; Helena Stabile; Alessandra Soriani; Cinzia Fionda; Maria Teresa Petrucci; Elena Mariggio'; Maria Rosaria Ricciardi; Marco Cippitelli; Angela Gismondi; Angela Santoni; Alessandra Zingoni
Journal: Cancers (Basel) Date: 2018-11-29 Impact factor: 6.639

Review 10. Engineering of chimeric natural killer cell receptors to develop precision adoptive immunotherapies for cancer.

Authors: J Obajdin; D M Davies; J Maher
Journal: Clin Exp Immunol Date: 2020-07-25 Impact factor: 4.330