Homero Zapata-Chavira1, Marco Hernández-Guedea1, Julio César Jiménez-Pérez2, Edelmiro Pérez-Rodríguez1, Linda Muñoz-Espinosa2, Gerardo Muñoz-Maldonado3, Paula Cordero-Pérez1. 1. a Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José E. González" Servicio de Trasplantes , Monterrey , Nuevo León , México. 2. b Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José E. González" Departamento de Medicina Interna, Unidad de Hígado , Monterrey , Nuevo León , México. 3. c Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José E. González" Servicio de Cirugía General , Monterrey , Nuevo León , México.
Abstract
AIM: Remote ischemic preconditioning (RIPC) has been used as a strategy to reduce acute renal injury and ischemia-reperfusion injury (IRI) in renal transplantation (RT) with controversial results. OBJECTIVE: To determine if RIPC modifies IRI in cadaveric RT recipients through inflammatory mediators and graft function. METHODS: Twenty-nine RT recipients were studied, 12 in the control group (CG) and 17 in the RIPC group. RIPC which was performed on donors using a pneumatic tourniquet placed on both thighs for 10 min followed by the determination of IL-1, IL-6, TNF-α, VEGF, and ICAM-1, and hematological and biochemical parameters in different phases of RT. RESULTS: Serum creatinine levels were significantly lower in the RIPC group versus the CG at 15 and 30 days; however, the estimated glomerular filtration rate (eGFR) showed no significant difference in any phase between either group, only TNF-α showed significantly higher values in the RIPC group versus the CG in almost all phases of the study, meanwhile IL6 was increased at 72 hours (hr) and 30 days, IL1 at 72 hr and 15 days and ICAM-1 post reperfusion, contrary to this VEGF showed a decrease at 7 and 15 days. CONCLUSION: RIPC did not improve eGFR or serum creatinine; however, it modifies the inflammatory response in RT recipients.
AIM: Remote ischemic preconditioning (RIPC) has been used as a strategy to reduce acute renal injury and ischemia-reperfusion injury (IRI) in renal transplantation (RT) with controversial results. OBJECTIVE: To determine if RIPC modifies IRI in cadaveric RT recipients through inflammatory mediators and graft function. METHODS: Twenty-nine RT recipients were studied, 12 in the control group (CG) and 17 in the RIPC group. RIPC which was performed on donors using a pneumatic tourniquet placed on both thighs for 10 min followed by the determination of IL-1, IL-6, TNF-α, VEGF, and ICAM-1, and hematological and biochemical parameters in different phases of RT. RESULTS: Serum creatinine levels were significantly lower in the RIPC group versus the CG at 15 and 30 days; however, the estimated glomerular filtration rate (eGFR) showed no significant difference in any phase between either group, only TNF-α showed significantly higher values in the RIPC group versus the CG in almost all phases of the study, meanwhile IL6 was increased at 72 hours (hr) and 30 days, IL1 at 72 hr and 15 days and ICAM-1 post reperfusion, contrary to this VEGF showed a decrease at 7 and 15 days. CONCLUSION:RIPC did not improve eGFR or serum creatinine; however, it modifies the inflammatory response in RT recipients.
Authors: Eduardo Cienfuegos-Pecina; Diana P Moreno-Peña; Liliana Torres-González; Diana Raquel Rodríguez-Rodríguez; Diana Garza-Villarreal; Oscar H Mendoza-Hernández; Raul Alejandro Flores-Cantú; Brenda Alejandra Samaniego Sáenz; Gabriela Alarcon-Galvan; Linda E Muñoz-Espinosa; Tannya R Ibarra-Rivera; Alma L Saucedo; Paula Cordero-Pérez Journal: PeerJ Date: 2021-11-12 Impact factor: 2.984
Authors: Aki Uutela; Ilkka Helanterä; Karl Lemström; Arie Passov; Simo Syrjälä; Fredrik Åberg; Heikki Mäkisalo; Arno Nordin; Marko Lempinen; Ville Sallinen Journal: BMJ Open Date: 2020-11-16 Impact factor: 2.692