Michael Karsy1, Jian Guan1, Andrea A Brock1, Anubhav Amin2, Min S Park3,4. 1. Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175 North Medical Drive East, Salt Lake City, UT, 84132, USA. 2. Department of Neurosurgery, New York Medical College, Valhalla, NY, USA. 3. Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175 North Medical Drive East, Salt Lake City, UT, 84132, USA. neuropub@hsc.utah.edu. 4. Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA. neuropub@hsc.utah.edu.
Abstract
PURPOSE OF REVIEW: Stents and flow diverters have revolutionized the treatment of cerebrovascular disease. Guglielmi coils, flexible microcatheters, and first-generation intracranial stents, such as Neuroform (Stryker Neurovascular) and Enterprise stents (Codman/DePuy-Synthes), have paved the way for the development of the Pipeline Embolization Device (PED) (ev3/Covidien/Medtronic) and other endovascular approaches. RECENT FINDINGS: This review discusses the historical development of flow diverter technologies from the PED to similar devices, such as the Surpass stent (Stryker Neurovascular), the Flow-Redirection Endoluminal Device (FRED; MicroVention, Inc.), the SILK stent (Balt Extrusion), and the p64 Flow Modulation Device (Phenox). In addition, the potential use of drug-eluting stents and various bioresorbable scaffolds (e.g., poly-L-lactic acid, magnesium), new developments in stent material (e.g., thin-film nitinol), design (e.g., biocompatible polymers, embedded microcircuitry, flow models), and potential applications for flow diverters will be considered. Endovascular treatment of cerebrovascular disease is rapidly advancing via continued development of new technology.
PURPOSE OF REVIEW: Stents and flow diverters have revolutionized the treatment of cerebrovascular disease. Guglielmi coils, flexible microcatheters, and first-generation intracranial stents, such as Neuroform (Stryker Neurovascular) and Enterprise stents (Codman/DePuy-Synthes), have paved the way for the development of the Pipeline Embolization Device (PED) (ev3/Covidien/Medtronic) and other endovascular approaches. RECENT FINDINGS: This review discusses the historical development of flow diverter technologies from the PED to similar devices, such as the Surpass stent (Stryker Neurovascular), the Flow-Redirection Endoluminal Device (FRED; MicroVention, Inc.), the SILK stent (Balt Extrusion), and the p64 Flow Modulation Device (Phenox). In addition, the potential use of drug-eluting stents and various bioresorbable scaffolds (e.g., poly-L-lactic acid, magnesium), new developments in stent material (e.g., thin-film nitinol), design (e.g., biocompatible polymers, embedded microcircuitry, flow models), and potential applications for flow diverters will be considered. Endovascular treatment of cerebrovascular disease is rapidly advancing via continued development of new technology.
Authors: Ajay J Kirtane; Anuj Gupta; Srinivas Iyengar; Jeffrey W Moses; Martin B Leon; Robert Applegate; Bruce Brodie; Edward Hannan; Kishore Harjai; Lisette Okkels Jensen; Seung-Jung Park; Raphael Perry; Michael Racz; Francesco Saia; Jack V Tu; Ron Waksman; Alexandra J Lansky; Roxana Mehran; Gregg W Stone Journal: Circulation Date: 2009-06-15 Impact factor: 29.690
Authors: Peter Wenaweser; Joost Daemen; Marcel Zwahlen; Ron van Domburg; Peter Jüni; Sophia Vaina; Gerrit Hellige; Keiichi Tsuchida; Cyrill Morger; Eric Boersma; Neville Kukreja; Bernhard Meier; Patrick W Serruys; Stephan Windecker Journal: J Am Coll Cardiol Date: 2008-09-30 Impact factor: 24.094
Authors: Aradhana Yoganand; Rachel P Wood; Carlos Jimenez; Adnan Siddiqui; Kenneth Snyder; S V Setlur Nagesh; D R Bednarek; S Rudin; Robert Baier; Ciprian N Ionita Journal: Proc SPIE Int Soc Opt Eng Date: 2015-03-17
Authors: Shuzou Tanimoto; Patrick W Serruys; Leif Thuesen; Dariusz Dudek; Bernard de Bruyne; Bernard Chevalier; John A Ormiston Journal: Catheter Cardiovasc Interv Date: 2007-10-01 Impact factor: 2.692
Authors: Stefan Verheye; John A Ormiston; James Stewart; Mark Webster; Elias Sanidas; Ricardo Costa; J Ribamar Costa; Daniel Chamie; Andrea S Abizaid; Ibraim Pinto; Lynn Morrison; Sara Toyloy; Vinayak Bhat; John Yan; Alexandre Abizaid Journal: JACC Cardiovasc Interv Date: 2013-10-16 Impact factor: 11.195