Rui-Xue Dai1, Xiu-Jie He2, Chuan-Lai Hu3,4. 1. Disease Control Center of Fuyang, 19 Zhongnan Road, Yingzhou district, Fuyang, 236000, Anhui, China. 2. Fuyang Hospital of Anhui Medical University, 99 Huangshan Road, Yingzhou district, Fuyang, 236000, Anhui, China. hexiujieahmu@126.com. 3. Fuyang Hospital of Anhui Medical University, 99 Huangshan Road, Yingzhou district, Fuyang, 236000, Anhui, China. 4. The Division of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, 81 Mei Shan Road, Hefei, 230032, Anhui, China.
Abstract
PURPOSE: The aim of our meta-analysis was to explore whether pre-pregnancy obesity is regarded as an important risk factor for predicting macrosomia or not. METHODS: Three databases were systematically reviewed and reference lists of relevant articles were checked. Meta-analysis of published cohort studies comparing whether pre-pregnancy obesity was associated with macrosomia and adjusting for potential confounding factors. Calculations of pooled estimates were conducted in random-effect model. Heterogeneity was tested by using Chi-square test and I 2 statistics. Publication bias was estimated from Egger's test (linear regression method) and Begg's test (rank correlation method). RESULTS: Sixteen cohort studies met the inclusion criteria. The meta-analysis showed that pre-pregnancy obesity was associated with macrosomia as an important risk factor. The adjusted odds ratio was 1.93, 95% CI (1.65, 2.27) in random-effect model, stratified analyses showed no differences regarding different quality grade, definition of macrosomia, location of study and number of confounding factors adjusted for. There was no indication of a publication bias either from the result of Egger's test or Begg's test. CONCLUSION: Our findings indicated that pre-pregnancy obesity should be considered as an important risk factor for macrosomia. The effect of pre-pregnancy obesity on macrosomia need to be carefully assessed and monitored.
PURPOSE: The aim of our meta-analysis was to explore whether pre-pregnancy obesity is regarded as an important risk factor for predicting macrosomia or not. METHODS: Three databases were systematically reviewed and reference lists of relevant articles were checked. Meta-analysis of published cohort studies comparing whether pre-pregnancy obesity was associated with macrosomia and adjusting for potential confounding factors. Calculations of pooled estimates were conducted in random-effect model. Heterogeneity was tested by using Chi-square test and I 2 statistics. Publication bias was estimated from Egger's test (linear regression method) and Begg's test (rank correlation method). RESULTS: Sixteen cohort studies met the inclusion criteria. The meta-analysis showed that pre-pregnancy obesity was associated with macrosomia as an important risk factor. The adjusted odds ratio was 1.93, 95% CI (1.65, 2.27) in random-effect model, stratified analyses showed no differences regarding different quality grade, definition of macrosomia, location of study and number of confounding factors adjusted for. There was no indication of a publication bias either from the result of Egger's test or Begg's test. CONCLUSION: Our findings indicated that pre-pregnancy obesity should be considered as an important risk factor for macrosomia. The effect of pre-pregnancy obesity on macrosomia need to be carefully assessed and monitored.
Authors: S De Carolis; A Botta; Gelsomina Del Sordo; R Guerrisi; S Salvi; M P De Carolis; A Iaconelli; P Giustacchini; M Raffaelli; A Lanzone Journal: Obes Surg Date: 2018-10 Impact factor: 4.129
Authors: Lars Brodowski; Wolfgang Büter; Fabian Kohls; Peter Hillemanns; Constantin von Kaisenberg; Olaf Dammann Journal: Geburtshilfe Frauenheilkd Date: 2019-11-11 Impact factor: 2.915
Authors: Lje Meertens; Ljm Smits; Smj van Kuijk; R Aardenburg; Ima van Dooren; J Langenveld; I M Zwaan; Mea Spaanderman; Hcj Scheepers Journal: BJOG Date: 2019-01-17 Impact factor: 6.531