T Peng1,2, G Zhao2, L Wang3, J Wu3, H Cui4, Y Liang1, R Zhou1, Z Liu5, Q Wang6. 1. Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China. 2. Department of Blood Transfusion, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China. 3. Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China. 4. Department of General Surgery, Beijing Hospital, No. 1 Dahua Road, Dongcheng District, Beijing, 100730, China. 5. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 26 Hua Cai Road, Dong San Huan Er Duan, Chengdu, 610052, China. 6. Department of Clinical Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China. wqt36@163.com.
Abstract
BACKGROUND: The relationship between perioperative blood transfusion and long-term survival after curative resection for hepatocellular carcinoma (HCC) remains controversial. The aim of the present study was to investigate the impact of blood transfusion on the long-term prognosis of HCC patients. METHODS: Patients with primary HCC who underwent a curative hepatectomy from 2003 to 2011 were enrolled and then retrospectively studied. The clinicopathologic characteristics between patients in the blood transfusion and non-transfusion groups were matched using a propensity score matching (PSM) analysis. Univariate and multivariate Cox regression analyses were used to identify whether perioperative blood transfusion affects long-term survival after resection for HCC. RESULTS: A total of 374 patients were enrolled and 113 patients received perioperative transfusions. The 1-, 3- and 5-year disease-free and overall survival rates of the entire cohort were 65.0, 37.3 and 23.9%, and 90.9, 70.7 and 57.5%, respectively. The disease-free and overall survival rates of the blood transfusion group were significantly worse than the disease-free and overall survival rates of the non-transfusion group in the entire cohort (p < 0.001, p < 0.001). However, the differences in the survival rates between the two groups were no longer significant after PSM (p = 0.067, p = 0.105). Multivariate Cox analyses showed that perioperative blood transfusion was not an independent predictor of disease-free and overall survival in the propensity-matched cohort (p = 0.154, p = 0.667). CONCLUSIONS: The present study demonstrates that perioperative blood transfusion has no impact on disease-free and overall survival after curative resection for HCC.
BACKGROUND: The relationship between perioperative blood transfusion and long-term survival after curative resection for hepatocellular carcinoma (HCC) remains controversial. The aim of the present study was to investigate the impact of blood transfusion on the long-term prognosis of HCC patients. METHODS:Patients with primary HCC who underwent a curative hepatectomy from 2003 to 2011 were enrolled and then retrospectively studied. The clinicopathologic characteristics between patients in the blood transfusion and non-transfusion groups were matched using a propensity score matching (PSM) analysis. Univariate and multivariate Cox regression analyses were used to identify whether perioperative blood transfusion affects long-term survival after resection for HCC. RESULTS: A total of 374 patients were enrolled and 113 patients received perioperative transfusions. The 1-, 3- and 5-year disease-free and overall survival rates of the entire cohort were 65.0, 37.3 and 23.9%, and 90.9, 70.7 and 57.5%, respectively. The disease-free and overall survival rates of the blood transfusion group were significantly worse than the disease-free and overall survival rates of the non-transfusion group in the entire cohort (p < 0.001, p < 0.001). However, the differences in the survival rates between the two groups were no longer significant after PSM (p = 0.067, p = 0.105). Multivariate Cox analyses showed that perioperative blood transfusion was not an independent predictor of disease-free and overall survival in the propensity-matched cohort (p = 0.154, p = 0.667). CONCLUSIONS: The present study demonstrates that perioperative blood transfusion has no impact on disease-free and overall survival after curative resection for HCC.
Authors: Camelia S Sima; William R Jarnagin; Yuman Fong; Elena Elkin; Mary Fischer; David Wuest; Michael D'Angelica; Ronald P DeMatteo; Leslie H Blumgart; Mithat Gönen Journal: Ann Surg Date: 2009-12 Impact factor: 12.969
Authors: Gang Huang; Eric C H Lai; Wan Yee Lau; Wei-ping Zhou; Feng Shen; Ze-ya Pan; Si-yuan Fu; Meng-chao Wu Journal: Ann Surg Date: 2013-03 Impact factor: 12.969