BACKGROUND: Although liver resection is now a safe procedure, its role for hepatocellular carcinoma (HCC) in patients with cirrhosis remains controversial. METHODS: This study compared the results of liver resection for HCC in patients with cirrhosis over two time intervals. One hundred and sixty-one patients had resection during period 1 (1991-1996) and 265 in period 2 (1997-2002). Early and long-term results after liver resection in the two periods were compared, and clinicopathological characteristics that influenced survival were identified. RESULTS: Tumour size was smaller, indocyanine green retention rate was higher, patients were older and a greater proportion of patients were asymptomatic in period 2 than period 1. Operative blood loss, need for blood transfusion, operative mortality rate, postoperative hospital stay and total hospital costs were significantly reduced in period 2. The 5-year disease-free survival rates were 28.2 and 33.9 per cent in periods 1 and 2 respectively (P = 0.042), and 5-year overall survival rates were 45.9 and 61.2 per cent (P < 0.001). Multivariate analysis identified serum alpha-fetoprotein level, need for blood transfusion and Union Internacional Contra la Cancrum tumour node metastasis stage as independent determinants of disease-free and overall survival. CONCLUSION: The results of liver resection for HCC in patients with cirrhosis improved over time. Liver resection remains a good treatment option in selected patients with HCC arising from a cirrhotic liver. Copyright (c) 2005 British Journal of Surgery Society Ltd.
BACKGROUND: Although liver resection is now a safe procedure, its role for hepatocellular carcinoma (HCC) in patients with cirrhosis remains controversial. METHODS: This study compared the results of liver resection for HCC in patients with cirrhosis over two time intervals. One hundred and sixty-one patients had resection during period 1 (1991-1996) and 265 in period 2 (1997-2002). Early and long-term results after liver resection in the two periods were compared, and clinicopathological characteristics that influenced survival were identified. RESULTS: Tumour size was smaller, indocyanine green retention rate was higher, patients were older and a greater proportion of patients were asymptomatic in period 2 than period 1. Operative blood loss, need for blood transfusion, operative mortality rate, postoperative hospital stay and total hospital costs were significantly reduced in period 2. The 5-year disease-free survival rates were 28.2 and 33.9 per cent in periods 1 and 2 respectively (P = 0.042), and 5-year overall survival rates were 45.9 and 61.2 per cent (P < 0.001). Multivariate analysis identified serum alpha-fetoprotein level, need for blood transfusion and Union Internacional Contra la Cancrum tumour node metastasis stage as independent determinants of disease-free and overall survival. CONCLUSION: The results of liver resection for HCC in patients with cirrhosis improved over time. Liver resection remains a good treatment option in selected patients with HCC arising from a cirrhotic liver. Copyright (c) 2005 British Journal of Surgery Society Ltd.
Authors: Kota Sahara; Anghela Z Paredes; Diamantis I Tsilimigras; J Madison Hyer; Katiuscha Merath; Lu Wu; Rittal Mehta; Eliza W Beal; Susan White; Itaru Endo; Timothy M Pawlik Journal: J Gastrointest Surg Date: 2019-02-04 Impact factor: 3.452
Authors: Peng Yao; Frank Chu; Steve Daniel; Aravin Gunasegaram; Tristan Yan; Werner Lindemann; Georg Pistorius; Martin Schilling; Junji Machi; Randall Zuckerman; David L Morris Journal: HPB (Oxford) Date: 2007 Impact factor: 3.647
Authors: Sung Hoon Choi; Gi Hong Choi; Seung Up Kim; Jun Yong Park; Dong Jin Joo; Man Ki Ju; Myoung Soo Kim; Jin Sub Choi; Kwang Hyub Han; Soon Il Kim Journal: World J Gastroenterol Date: 2013-01-21 Impact factor: 5.742