Literature DB >> 29078288

PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters.

Jennifer M Gerlach1, Michael Furrer2, Maria Gallant1, Dirk Birkel1, Apoorva Baluapuri1, Elmar Wolf1, Peter Gallant3,4.   

Abstract

The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters. Published under the PNAS license.

Entities:  

Keywords:  Drosophila; Myc; PAF1; growth; transcription

Mesh：

Substances：

Year:  2017        PMID： 29078288      PMCID： PMC5676885          DOI： 10.1073/pnas.1705816114

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  70 in total

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2.  A guided tour into subcellular colocalization analysis in light microscopy.

Authors:  S Bolte; F P Cordelières
Journal:  J Microsc       Date:  2006-12       Impact factor: 1.758

Review 3.  MYC and transcription elongation.

Authors:  Peter B Rahl; Richard A Young
Journal:  Cold Spring Harb Perspect Med       Date:  2014-01-01       Impact factor: 6.915

4.  Myc and Max homologs in Drosophila.

Authors:  P Gallant; Y Shiio; P F Cheng; S M Parkhurst; R N Eisenman
Journal:  Science       Date:  1996-11-29       Impact factor: 47.728

5.  Transcriptional amplification in tumor cells with elevated c-Myc.

Authors:  Charles Y Lin; Jakob Lovén; Peter B Rahl; Ronald M Paranal; Christopher B Burge; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

6.  c-Myc regulates mammalian body size by controlling cell number but not cell size.

Authors:  A Trumpp; Y Refaeli; T Oskarsson; S Gasser; M Murphy; G R Martin; J M Bishop
Journal:  Nature       Date:  2001-12-13       Impact factor: 49.962

7.  HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome.

Authors:  J D Carpten; C M Robbins; A Villablanca; L Forsberg; S Presciuttini; J Bailey-Wilson; W F Simonds; E M Gillanders; A M Kennedy; J D Chen; S K Agarwal; R Sood; M P Jones; T Y Moses; C Haven; D Petillo; P D Leotlela; B Harding; D Cameron; A A Pannett; A Höög; H Heath; L A James-Newton; B Robinson; R J Zarbo; B M Cavaco; W Wassif; N D Perrier; I B Rosen; U Kristoffersson; P D Turnpenny; L-O Farnebo; G M Besser; C E Jackson; H Morreau; J M Trent; R V Thakker; S J Marx; B T Teh; C Larsson; M R Hobbs
Journal:  Nat Genet       Date:  2002-11-18       Impact factor: 38.330

8.  The human PAF complex coordinates transcription with events downstream of RNA synthesis.

Authors:  Bing Zhu; Subhrangsu S Mandal; Anh-Dung Pham; Yong Zheng; Hediye Erdjument-Bromage; Surinder K Batra; Paul Tempst; Danny Reinberg
Journal:  Genes Dev       Date:  2005-07-15       Impact factor: 11.361

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Authors:  Victoria H Cowling; Michael D Cole
Journal:  Mol Cell Biol       Date:  2007-01-22       Impact factor: 4.272

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  14 in total

Review 1.  Target gene-independent functions of MYC oncoproteins.

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2.  Blood feeding activates the vitellogenic stage of oogenesis in the mosquito Aedes aegypti through inhibition of glycogen synthase kinase 3 by the insulin and TOR pathways.

Authors:  Luca Valzania; Melissa T Mattee; Michael R Strand; Mark R Brown
Journal:  Dev Biol       Date:  2019-05-30       Impact factor: 3.582

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Authors:  Zhuojuan Luo; Xiaoxu Liu; Hao Xie; Yan Wang; Chengqi Lin
Journal:  Mol Cell Biol       Date:  2019-11-25       Impact factor: 4.272

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Journal:  Mol Cell       Date:  2021-12-09       Impact factor: 17.970

5.  Parafibromin governs cell polarity and centrosome assembly in Drosophila neural stem cells.

Authors:  Qiannan Deng; Cheng Wang; Chwee Tat Koe; Jan Peter Heinen; Ye Sing Tan; Song Li; Cayetano Gonzalez; Wing-Kin Sung; Hongyan Wang
Journal:  PLoS Biol       Date:  2022-10-12       Impact factor: 9.593

Review 6.  New Roles for Canonical Transcription Factors in Repeat Expansion Diseases.

Authors:  Lindsey D Goodman; Nancy M Bonini
Journal:  Trends Genet       Date:  2019-12-11       Impact factor: 11.639

7.  Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters.

Authors:  Theresa Endres; Daniel Solvie; Jan B Heidelberger; Valentina Andrioletti; Apoorva Baluapuri; Carsten P Ade; Matthias Muhar; Ursula Eilers; Seychelle M Vos; Patrick Cramer; Johannes Zuber; Petra Beli; Nikita Popov; Elmar Wolf; Peter Gallant; Martin Eilers
Journal:  Mol Cell       Date:  2021-01-15       Impact factor: 17.970

8.  WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways.

Authors:  Tianli Chen; Kangshuai Li; Zengli Liu; Jialiang Liu; Yue Wang; Rongqi Sun; Zhipeng Li; Bo Qiu; Xiaoming Zhang; Guangli Ren; Yunfei Xu; Zongli Zhang
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9.  MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.

Authors:  Apoorva Baluapuri; Julia Hofstetter; Nevenka Dudvarski Stankovic; Theresa Endres; Pranjali Bhandare; Seychelle Monique Vos; Bikash Adhikari; Jessica Denise Schwarz; Ashwin Narain; Markus Vogt; Shuang-Yan Wang; Robert Düster; Lisa Anna Jung; Jens Thorsten Vanselow; Armin Wiegering; Matthias Geyer; Hans Michael Maric; Peter Gallant; Susanne Walz; Andreas Schlosser; Patrick Cramer; Martin Eilers; Elmar Wolf
Journal:  Mol Cell       Date:  2019-03-27       Impact factor: 17.970

10.  The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.

Authors:  Michael J Jurynec; Xiaoying Bai; Brent W Bisgrove; Haley Jackson; Alex Nechiporuk; Rebecca A S Palu; Hannah A Grunwald; Yi-Chu Su; Kazuyuki Hoshijima; H Joseph Yost; Leonard I Zon; David Jonah Grunwald
Journal:  Development       Date:  2019-12-16       Impact factor: 6.868
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