Literature DB >> 29078003

Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis.

Kirsten Dietze-Schwonberg1, Beate Lorenz1, Susanna Lopez Kostka1, Beatrix Schumak2, André Gessner3, Esther von Stebut1.   

Abstract

Healing of leishmaniasis-a parasitic skin disease-is associated with high levels of secreted interferon (IFN)γ and IL-12 in resistant C57BL/6 mice and humans. Susceptible BALB/c mice predominantly react with a Th17/Th2/Treg-related immune response and finally succumb to infection. Previously, we showed that BALB/c IL-17A-/- mice are protected against Leishmania (L.) major infections, indicating that IL-17A-predominantly produced by Th17 cells-plays an important role for disease outcome. We now investigated DC-derived cytokines and finally identified IL-23p19 as key cytokine responsible for induction of Leishmania-specific Th17 cells that play an important role for progressive disease in susceptible BALB/c mice.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  IL-23; Leishmaniasis; Pathogenic; Th17

Mesh：

Substances：

Year:  2017        PMID： 29078003     DOI： 10.1111/exd.13455

Source DB:  PubMed          Journal:  Exp Dermatol        ISSN： 0906-6705            Impact factor:   3.960


  4 in total

Review 1.  Cytokines and Signaling Networks Regulating Disease Outcomes in Leishmaniasis.

Authors:  Amrita Saha; Souravi Roy; Anindita Ukil
Journal:  Infect Immun       Date:  2022-07-11       Impact factor: 3.609

2.  The level of interleukin-17, 23, and gamma interferon in cutaneous leishmaniasis patients before and after intra lesion treatment.

Authors:  Mehdi Ghazanfari; Bahador Shahriari; Vahid Rahnama; Meisam Khazaei; Shahrbanou Naderi; Mohammad Hossein Motazedian
Journal:  J Parasit Dis       Date:  2022-02-03

3.  Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A.

Authors:  Tiffany Y Borbón; Breanna M Scorza; Gwendolyn M Clay; Fellipe Lima Nobre de Queiroz; Alan J Sariol; Jayden L Bowen; Yani Chen; Bayan Zhanbolat; Corey P Parlet; Diogo G Valadares; Suzanne L Cassel; William M Nauseef; Alexander R Horswill; Fayyaz S Sutterwala; Mary E Wilson
Journal:  PLoS Negl Trop Dis       Date:  2019-05-20

4.  MicroRNA expression profile in chronic nonbacterial prostatitis revealed by next-generation small RNA sequencing.

Authors:  Li Zhang; Yi Liu; Xian-Guo Chen; Yong Zhang; Jing Chen; Zong-Yao Hao; Song Fan; Li-Gang Zhang; He-Xi Du; Chao-Zhao Liang
Journal:  Asian J Androl       Date:  2019 Jul-Aug       Impact factor: 3.285
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.