OBJECTIVE: To quantify the presence of cardiorespiratory interaction in a group of 41 healthy subjects performing a subset of the Ewing test battery. APPROACH: We measure the empirical distribution of the cardiorespiratory coupling time (RI), defined as the time from inspiration onset to R peaks in the ECG. The study protocol is a subset of the Ewing test battery. The respiratory function was measured with a thoracic belt and heart rate was obtained from a two channel ECG measurement. Both series of fiducial points were determined using custom software. Additionally, we determine the presence of cardiorespiratory coupling (CRC) and cardiorespiratory interaction (CRI) using Shannon entropy, synchrograms and coordigrams. MAIN RESULTS: We observe that the RI distribution is asymmetric and nonuniform. These features are a manifestation of the causal relation between heart action and respiration. The preceding R peak strongly affects a position of inspiration onset. From the asymmetry of the RI distribution we conclude that this relation is stronger than the relation between inspiration onset and the following R peak. We use a suitable choice of surrogate data to prove that the result cannot be falsified. We observe a dual structure of the RI histograms, which may be related to the respiratory rhythmogenesis. We compare the sensitivity of RI histograms with other measures of CRI and CRC. In 46% of subjects, CRC appears in at least one stage of the examination, most often in resting states. In states of increased stress-orthostasis or physical (exercise)-the strength of coupling is visibly diminished. The nonuniform structure of the RI histogram is more sensitive to the presence of CRI than synchrograms or coordigrams are, as is well visible in the group averages. We also refer to the question of the most proper mathematical description of cardiorespiratory dynamics (phase domain or time domain). Finally, we formulate the hypothesis that the arterial blood pressure is a common driver of cardiac and respiratory rhythms. SIGNIFICANCE: Analysis of the asymmetry of RI histograms is an interesting and sensitive method to study cardiorespiratory interaction and autonomic balance, in order to assess physical and mental health. The dual structure of the RI histograms which we have observed suggests the possible presence of a twofold mechanism for respiratory rhythmogenesis, as proposed by Galletly and Larsen.
OBJECTIVE: To quantify the presence of cardiorespiratory interaction in a group of 41 healthy subjects performing a subset of the Ewing test battery. APPROACH: We measure the empirical distribution of the cardiorespiratory coupling time (RI), defined as the time from inspiration onset to R peaks in the ECG. The study protocol is a subset of the Ewing test battery. The respiratory function was measured with a thoracic belt and heart rate was obtained from a two channel ECG measurement. Both series of fiducial points were determined using custom software. Additionally, we determine the presence of cardiorespiratory coupling (CRC) and cardiorespiratory interaction (CRI) using Shannon entropy, synchrograms and coordigrams. MAIN RESULTS: We observe that the RI distribution is asymmetric and nonuniform. These features are a manifestation of the causal relation between heart action and respiration. The preceding R peak strongly affects a position of inspiration onset. From the asymmetry of the RI distribution we conclude that this relation is stronger than the relation between inspiration onset and the following R peak. We use a suitable choice of surrogate data to prove that the result cannot be falsified. We observe a dual structure of the RI histograms, which may be related to the respiratory rhythmogenesis. We compare the sensitivity of RI histograms with other measures of CRI and CRC. In 46% of subjects, CRC appears in at least one stage of the examination, most often in resting states. In states of increased stress-orthostasis or physical (exercise)-the strength of coupling is visibly diminished. The nonuniform structure of the RI histogram is more sensitive to the presence of CRI than synchrograms or coordigrams are, as is well visible in the group averages. We also refer to the question of the most proper mathematical description of cardiorespiratory dynamics (phase domain or time domain). Finally, we formulate the hypothesis that the arterial blood pressure is a common driver of cardiac and respiratory rhythms. SIGNIFICANCE: Analysis of the asymmetry of RI histograms is an interesting and sensitive method to study cardiorespiratory interaction and autonomic balance, in order to assess physical and mental health. The dual structure of the RI histograms which we have observed suggests the possible presence of a twofold mechanism for respiratory rhythmogenesis, as proposed by Galletly and Larsen.
Authors: Dmitriy Yu Uryumtsev; Valentina V Gultyaeva; Margarita I Zinchenko; Victor I Baranov; Vladimir N Melnikov; Natalia V Balioz; Sergey G Krivoschekov Journal: Front Physiol Date: 2020-06-30 Impact factor: 4.566