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Literature DB >> 2907404

Genetic determinants of glutamine synthetase in Drosophila melanogaster: a gene for glutamine synthetase I resides in the 21B3-6 region.

C Caggese¹, R Caizzi, M P Bozzetti, P Barsanti, F Ritossa.

Abstract

Recombinational and deletion mapping of electrophoretic variants of the glutamine synthetase I isozyme (GSI) in Drosophila melanogaster locates the gene in the 21B region on the second chromosome. We have conducted a genetic analysis of the region extending cytologically from 21A to 21B4-6. Recessive lethal mutations were generated by ethyl methanesulfonate (EMS) and ethyl nitrosourea (ENU) mutagenesis and by hybrid dysgenesis (HD). These lethals fall into seven functional groups, which were partially ordered by complementation with cytologically defined deficiencies of this region generated by hybrid dysgenesis. Two of the EMS- and two of the ENU-induced lethals fulfill biochemical criteria expected for null alleles of the GSI gene.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Glutamate-Ammonia Ligase

Year: 1988 PMID： 2907404 DOI： 10.1007/BF02399602

Source DB: PubMed Journal: Biochem Genet ISSN： 0006-2928 Impact factor: 1.890

20 in total

1. The Relation of Repeats to Position Effect in Drosophila Melanogaster.

Authors: E B Lewis
Journal: Genetics Date: 1945-03 Impact factor: 4.562

2. Two forms of glutamine synthetase in free-living root-nodule bacteria.

Authors: R A Darrow; R R Knotts
Journal: Biochem Biophys Res Commun Date: 1977-09-23 Impact factor: 3.575

3. Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells.

Authors: G Arad; A Freikopf; R G Kulka
Journal: Cell Date: 1976-05 Impact factor: 41.582

4. Cytosolic glutamine synthetase in higher plants. A comparative immunological study.

Authors: B Hirel; S F McNally; P Gadal; N Sumar; G R Stewart
Journal: Eur J Biochem Date: 1984-01-02

Review 5. Genetic control of nitrogen assimilation in bacteria.

Authors: B Magasanik
Journal: Annu Rev Genet Date: 1982 Impact factor: 16.830

6. Plant glutamine synthetase complements a glnA mutation in Escherichia coli.

Authors: S DasSarma; E Tischer; H M Goodman
Journal: Science Date: 1986-06-06 Impact factor: 47.728

7. Derivation-dependent distribution of insertion sites for a Drosophila transposon.

Authors: G Ising; K Block
Journal: Cold Spring Harb Symp Quant Biol Date: 1981

8. Immunochemical evidence for glutamine-mediated degradation of glutamine synthetase in cultured Chinese hamster cells.

Authors: G Milman; L S Portnoff; D C Tiemeier
Journal: J Biol Chem Date: 1975-02-25 Impact factor: 5.157

9. Hybrid dysgenesis in Drosophila melanogaster: the biology of female and male sterility.

Authors: W R Engels; C R Preston
Journal: Genetics Date: 1979-05 Impact factor: 4.562

10. Transcription of glnA in E. coli is stimulated by activator bound to sites far from the promoter.

Authors: L J Reitzer; B Magasanik
Journal: Cell Date: 1986-06-20 Impact factor: 41.582

5 in total

1. Mutations in the Drosophila melanogaster gene encoding S-adenosylmethionine synthetase [corrected] suppress position-effect variegation.

Authors: J Larsson; J Zhang; A Rasmuson-Lestander
Journal: Genetics Date: 1996-06 Impact factor: 4.562