Foteini G Skondra1, Despina Koletsi2, Theodore Eliades2, Eleftherios Terry R Farmakis3. 1. 1 Medical School, University of Patras , Rio, Greece . 2. 2 Clinic of Orthodontics and Paediatric Dentistry, Center of Dental Medicine, University of Zurich , Zurich, Switzerland . 3. 3 Department of Endodontics, Faculty of Dentistry, National and Kapodistrian University of Athens , Athens, Greece .
Abstract
OBJECTIVE: The study aimed to systematically appraise the evidence on the effects of low level laser therapy (LLLT) on bone healing following rapid maxillary expansion (RME). METHODS: Electronic search was performed in MEDLINE, Scopus, and Embase databases using appropriate Medical Subject Heading terms, with no time restriction. ClinicalTrials.gov ( www.clinicaltrials.gov ) was also searched using the terms "low level laser therapy" and "maxillary expansion." SELECTION CRITERIA: Original research articles on human clinical trials that involved both RME and LLLT were included. Animal studies were also assessed on an exploratory basis. RESULTS: The search strategy resulted in 12 publications (4 randomized controlled trials, 8 animal studies). In human studies, bone density was assessed radiographically (either two-dimensional or three-dimensional imaging). Regardless of the discrepancies in the intervention protocols, the total of the trials revealed that LLLT had stimulatory effects on bone regeneration after RME. The studies in animal models measured the formation and maturation of new bone qualitatively or quantitatively. CONCLUSIONS: Despite the limited evidence, LLLT seems to be a promising intervention for stimulating immediate bone regeneration and healing after midpalatal suture expansion. Long-term, randomized clinical trials are needed to formulate safe results and establish a reliable clinical protocol, rendering the method clinically applicable.
OBJECTIVE: The study aimed to systematically appraise the evidence on the effects of low level laser therapy (LLLT) on bone healing following rapid maxillary expansion (RME). METHODS: Electronic search was performed in MEDLINE, Scopus, and Embase databases using appropriate Medical Subject Heading terms, with no time restriction. ClinicalTrials.gov ( www.clinicaltrials.gov ) was also searched using the terms "low level laser therapy" and "maxillary expansion." SELECTION CRITERIA: Original research articles on human clinical trials that involved both RME and LLLT were included. Animal studies were also assessed on an exploratory basis. RESULTS: The search strategy resulted in 12 publications (4 randomized controlled trials, 8 animal studies). In human studies, bone density was assessed radiographically (either two-dimensional or three-dimensional imaging). Regardless of the discrepancies in the intervention protocols, the total of the trials revealed that LLLT had stimulatory effects on bone regeneration after RME. The studies in animal models measured the formation and maturation of new bone qualitatively or quantitatively. CONCLUSIONS: Despite the limited evidence, LLLT seems to be a promising intervention for stimulating immediate bone regeneration and healing after midpalatal suture expansion. Long-term, randomized clinical trials are needed to formulate safe results and establish a reliable clinical protocol, rendering the method clinically applicable.
Authors: Angela Maria Paiva Magri; Kelly Rossetti Fernandes; Hueliton Wilian Kido; Gabriela Sodano Fernandes; Stephanie de Souza Fermino; Paulo Roberto Gabbai-Armelin; Franscisco José Correa Braga; Cíntia Pereirade Góes; José Lucas Dos Santos Prado; Renata Neves Granito; Ana Claudia Muniz Rennó Journal: J Mater Sci Mater Med Date: 2019-09-07 Impact factor: 3.896
Authors: Angela Maria Paiva Magri; Kelly Rossetti Fernandes; Hueliton Wilian Kido; Gabriela Sodano Fernandes; Stephanie de Souza Fermino; Paulo Roberto Gabbai-Armelin; Franscisco José Correa Braga; Cintia Pereira de Góes; José Lucas Dos Santos Prado; Renata Neves Granito; Ana Claudia Muniz Rennó Journal: Laser Ther Date: 2019-09-30
Authors: Eduardo Vasques da Fonseca; Sandra Kalil Bussadori; Luiz Felipe Cabral da Silva Martinho; Maria Carolina de Sousa Melo; Felipe Ledo de Andrade; Marcela Leticia Leal Gonçalves; Raquel Agnelli Mesquita-Ferrari; Anna Carolina Ratto Tempestini Horliana; Kristianne Porta Santos Fernandes Journal: Medicine (Baltimore) Date: 2019-11 Impact factor: 1.817