Yamini Krishna1, Luciane D Irion2, Sozan Karim3, Aruna Dharmsena4, Austin McCormick5, Sarah E Coupland1,3. 1. Department of Cellular Pathology, Royal Liverpool and Broadgreen University Hospital Trust, Liverpool, UK. 2. Department of Histopathology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. 3. Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK. 4. Department of Ophthalmology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. 5. Department of Ophthalmology, Aintree University Hospital, Liverpool, UK.
Abstract
BACKGROUND: Lymphomas of the lacrimal sac are rare, accounting for less than 10% of lacrimal sac malignant tumours. They may present with symptoms typical of secondary acquired nasolacrimal duct obstruction and are thus often misdiagnosed. METHODS: Case series and literature review. RESULTS: Herein we describe 3 cases of chronic lymphocytic leukaemia (CLL)/small-cell lymphocytic lymphoma (SLL) of the lacrimal sac with immunohistochemical and in 1 case molecular confirmation. CONCLUSION: Lymphomas of the lacrimal sac should be suspected in patients with known CLL presenting with epiphora and dacryocystitis. During dacryocystorhinostomy, an incisional biopsy of the lacrimal sac is essential for confirming CLL/SLL involvement and may guide treatment.
BACKGROUND:Lymphomas of the lacrimal sac are rare, accounting for less than 10% of lacrimal sac malignant tumours. They may present with symptoms typical of secondary acquired nasolacrimal duct obstruction and are thus often misdiagnosed. METHODS: Case series and literature review. RESULTS: Herein we describe 3 cases of chronic lymphocytic leukaemia (CLL)/small-cell lymphocytic lymphoma (SLL) of the lacrimal sac with immunohistochemical and in 1 case molecular confirmation. CONCLUSION:Lymphomas of the lacrimal sac should be suspected in patients with known CLL presenting with epiphora and dacryocystitis. During dacryocystorhinostomy, an incisional biopsy of the lacrimal sac is essential for confirming CLL/SLL involvement and may guide treatment.
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