Literature DB >> 29067835

Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.

Amr El-Demerdash1,2, Céline Moriou1, Marie-Thérèse Martin1, Sylvain Petek3,4, Cécile Debitus3,4, Ali Al-Mourabit1.   

Abstract

Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2-3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range.

Entities:  

Keywords:  Crambeidae; Monanchora; guanidine; spermidine alkaloid; unguiculin

Mesh：

Substances：

Year:  2017        PMID： 29067835     DOI： 10.1080/14786419.2017.1385011

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  7 in total

1.  Investigating the structure-activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors.

Authors:  Amr El-Demerdash; Ahmed A Al-Karmalawy; Tarek Mohamed Abdel-Aziz; Sameh S Elhady; Khaled M Darwish; Ahmed H E Hassan
Journal:  RSC Adv       Date:  2021-09-22       Impact factor: 4.036

Review 2.  Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas.

Authors:  Amr El-Demerdash; Atanas G Atanasov; Anupam Bishayee; Mamdouh Abdel-Mogib; John N A Hooper; Ali Al-Mourabit
Journal:  Nutrients       Date:  2018-01-02       Impact factor: 5.717

Review 3.  Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria.

Authors:  Amr El-Demerdash; Mohamed A Tammam; Atanas G Atanasov; John N A Hooper; Ali Al-Mourabit; Anake Kijjoa
Journal:  Mar Drugs       Date:  2018-06-18       Impact factor: 5.118

4.  Apoptotic Induction and Anti-Migratory Effects of Rhazya Stricta Fruit Extracts on a Human Breast Cancer Cell Line.

Authors:  Mohammed Al-Zharani; Fahd A Nasr; Nael Abutaha; Ali S Alqahtani; Omar M Noman; Mohammed Mubarak; Muhammad A Wadaan
Journal:  Molecules       Date:  2019-11-01       Impact factor: 4.411

Review 5.  Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review.

Authors:  Ahmed M Elissawy; Ebrahim Soleiman Dehkordi; Negin Mehdinezhad; Mohamed L Ashour; Pardis Mohammadi Pour
Journal:  Biomolecules       Date:  2021-02-10

6.  Identification of Fromiamycalin and Halaminol A from Australian Marine Sponge Extracts with Anthelmintic Activity against Haemonchus contortus.

Authors:  H M P Dilrukshi Herath; Sarah Preston; Abdul Jabbar; Jose Garcia-Bustos; Aya C Taki; Russell S Addison; Sasha Hayes; Karren D Beattie; Sean L McGee; Sheree D Martin; Merrick G Ekins; John N A Hooper; Bill C H Chang; Andreas Hofmann; Rohan A Davis; Robin B Gasser
Journal:  Mar Drugs       Date:  2019-10-23       Impact factor: 5.118

7.  Comprehensive Virtual Screening of the Antiviral Potentialities of Marine Polycyclic Guanidine Alkaloids against SARS-CoV-2 (COVID-19).

Authors:  Amr El-Demerdash; Ahmed M Metwaly; Afnan Hassan; Tarek Mohamed Abd El-Aziz; Eslam B Elkaeed; Ibrahim H Eissa; Reem K Arafa; James D Stockand
Journal:  Biomolecules       Date:  2021-03-19
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.