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Literature DB >> 29067365

Perdeuterated and ¹³C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase.

M J Moure¹, Y Zhuo, G J Boons, J H Prestegard.

Abstract

The synthesis of perdeuterated and 13C enriched myo-inositol is presented. Myo-inositol and its derivatives are of interest as substrates for enzymes producing phosphorylated species with regulatory functions in many organisms. Its utility in monitoring real-time phosphorylation by myo-inositol-3-kinase is illustrated using dynamic nuclear polarization (DNP) to enhance NMR observation.

Entities: CellLine Chemical Disease Species

Mesh：

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Year: 2017 PMID： 29067365 PMCID： PMC5690875 DOI： 10.1039/c7cc07023c

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

21 in total

1. Deuteration of a molecular probe for DNP hyperpolarization--a new approach and validation for choline chloride.

Authors: Hyla Allouche-Arnon; Mathilde H Lerche; Magnus Karlsson; Robert E Lenkinski; Rachel Katz-Brull
Journal: Contrast Media Mol Imaging Date: 2011 Nov-Dec Impact factor: 3.161

Review 2. The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Authors: Mark P Thomas; Stephen J Mills; Barry V L Potter
Journal: Angew Chem Int Ed Engl Date: 2015-12-22 Impact factor: 15.336

Review 3. Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins.

Authors: Shichong Yu; Zhongwu Guo; Charlie Johnson; Guofeng Gu; Qiuye Wu
Journal: Curr Opin Chem Biol Date: 2013-10-12 Impact factor: 8.822

Review 4. The role of the PI3K pathway in colorectal cancer.

Authors: Dionysios Papadatos-Pastos; Roy Rabbie; Paul Ross; Debashis Sarker
Journal: Crit Rev Oncol Hematol Date: 2014-12-25 Impact factor: 6.312

5. Novel synthesis of enantiomerically pure natural inositols and their diastereoisomers.

Authors: H Takahashi; H Kittaka; S Ikegami
Journal: J Org Chem Date: 2001-04-20 Impact factor: 4.354

Review 6. Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods.

Authors: Kerem Bingol; Rafael Brüschweiler
Journal: Curr Opin Biotechnol Date: 2016-08-20 Impact factor: 9.740

7. myo-Inositol Synthesis from [1-H]Glucose in Phaseolus vulgaris L. during Early Stages of Germination.

Authors: K Sasaki; I E Taylor
Journal: Plant Physiol Date: 1986-06 Impact factor: 8.340

Review 8. Phosphoinositides: Key modulators of energy metabolism.

Authors: Dave Bridges; Alan R Saltiel
Journal: Biochim Biophys Acta Date: 2014-11-20

9. An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity.

Authors: Takaaki Sato; Masahiro Fujihashi; Yukika Miyamoto; Keiko Kuwata; Eriko Kusaka; Haruo Fujita; Kunio Miki; Haruyuki Atomi
Journal: J Biol Chem Date: 2013-06-04 Impact factor: 5.157

Perdeuterated and ¹³C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase.

1. Deuteration of a molecular probe for DNP hyperpolarization--a new approach and validation for choline chloride.

Review 2. The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Review 3. Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins.

Review 4. The role of the PI3K pathway in colorectal cancer.

5. Novel synthesis of enantiomerically pure natural inositols and their diastereoisomers.

Review 6. Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods.

7. myo-Inositol Synthesis from [1-H]Glucose in Phaseolus vulgaris L. during Early Stages of Germination.

Review 8. Phosphoinositides: Key modulators of energy metabolism.

9. An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity.

10. Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei.

1. Harnessing ¹³C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR.

Review 2. Glycan structures and their interactions with proteins. A NMR view.

Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase.

1. Deuteration of a molecular probe for DNP hyperpolarization--a new approach and validation for choline chloride.

Review 2. The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Review 3. Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins.

Review 4. The role of the PI3K pathway in colorectal cancer.

5. Novel synthesis of enantiomerically pure natural inositols and their diastereoisomers.

Review 6. Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods.

7. myo-Inositol Synthesis from [1-H]Glucose in Phaseolus vulgaris L. during Early Stages of Germination.

Review 8. Phosphoinositides: Key modulators of energy metabolism.

9. An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity.

10. Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei.

1. Harnessing 13C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR.

Review 2. Glycan structures and their interactions with proteins. A NMR view.

Perdeuterated and ¹³C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase.

1. Harnessing ¹³C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR.