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Literature DB >> 29065980

Genistein: Its role in metabolic diseases and cancer.

Vidya Mukund¹, Dhruv Mukund², Vinay Sharma¹, Mastan Mannarapu³, Afroz Alam⁴.

Abstract

Genistein is an isoflavone present in soy and is known to have multiple molecular effects, such as the inhibition of inflammation, promotion of apoptosis, and modulation of steroidal hormone receptors and metabolic pathways. Since these molecular effects impact carcinogenesis, cancer propagation, obesity, osteoporosis, and metabolic syndromes, genistein plays an important role in preventing and treating common disorders. The role of genistein has not been adequately evaluated in all these clinical settings. This review summarizes some of the known molecular effects of genistein and its potential role in health maintenance and treatment.

Entities: Chemical Disease

Keywords: Adipogenesis; Cancer; Genistein; Insulin; Metabolic diseases

Mesh：

Substances：
Genistein

Year: 2017 PMID： 29065980 DOI： 10.1016/j.critrevonc.2017.09.004

Source DB: PubMed Journal: Crit Rev Oncol Hematol ISSN： 1040-8428 Impact factor: 6.312

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Cited

65 in total

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Authors: Stefania Bulotta; Francesca Capriglione; Marilena Celano; Valeria Pecce; Diego Russo; Valentina Maggisano
Journal: Endocrine Date: 2021-02-15 Impact factor: 3.633

2. Genistein ameliorates inflammation and insulin resistance through mediation of gut microbiota composition in type 2 diabetic mice.

Authors: Rui Yang; Qiang Jia; Shomaila Mehmood; Shanfeng Ma; Xiaofen Liu
Journal: Eur J Nutr Date: 2020-10-17 Impact factor: 5.614

3. Genistein antagonizes gliadin-induced CFTR malfunction in models of celiac disease.

Authors: Speranza Esposito; Valeria Rachela Villella; Eleonora Ferrari; Romina Monzani; Antonella Tosco; Federica Rossin; Manuela D'Eletto; Alice Castaldo; Alessandro Luciani; Marco Silano; Gianni Bona; Gian Luigi Marseglia; Luigina Romani; Mauro Piacentini; Valeria Raia; Guido Kroemer; Luigi Maiuri
Journal: Aging (Albany NY) Date: 2019-04-12 Impact factor: 5.682

4. Bio-enhancement of Soy Isoflavones (Genistein & Daidzein) Using Bacillus coagulans in Letrozole Induced Polycystic Ovarian Syndrome by Regulating Endocrine Hormones in Rats.

Authors: Jeshica Bulsara; Arun Soni; Pragati Patil; Kripa Halpati; Sonal Desai; Sanjeev Acharya
Journal: Probiotics Antimicrob Proteins Date: 2022-04-11 Impact factor: 4.609

Review 5. Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Authors: Wamidh H Talib; Izzeddin Alsalahat; Safa Daoud; Reem Fawaz Abutayeh; Asma Ismail Mahmod
Journal: Molecules Date: 2020-11-14 Impact factor: 4.411

Review 6. Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer's Disease.

Authors: Anna Atlante; Giuseppina Amadoro; Antonella Bobba; Valentina Latina
Journal: Cells Date: 2020-10-23 Impact factor: 6.600

Review 7. Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits.

Authors: Javad Sharifi-Rad; Cristina Quispe; Muhammad Imran; Abdur Rauf; Muhammad Nadeem; Tanweer Aslam Gondal; Bashir Ahmad; Muhammad Atif; Mohammad S Mubarak; Oksana Sytar; Oxana Mihailovna Zhilina; Ekaterina Robertovna Garsiya; Antonella Smeriglio; Domenico Trombetta; Daniel Gabriel Pons; Miquel Martorell; Susana M Cardoso; Ahmad Faizal Abdull Razis; Usman Sunusi; Ramla Muhammad Kamal; Lia Sanda Rotariu; Monica Butnariu; Anca Oana Docea; Daniela Calina
Journal: Oxid Med Cell Longev Date: 2021-07-19 Impact factor: 6.543