Julia R Berian1,2, Kristen A Ban2,3, Jason B Liu1,2, Clifford Y Ko2,4, Liane S Feldman5, Julie K Thacker6. 1. Department of Surgery, University of Chicago, Chicago, IL. 2. Division of Research and Optimal Patient Care, American College of Surgeons, Chicago, IL. 3. Department of Surgery, Loyola University Medical Center, Maywood, IL. 4. Department of Surgery, University of California Los Angeles, Los Angeles, CA. 5. Department of Surgery, McGill University, Montreal, CA. 6. Department of Surgery, Duke University, Durham, NC.
Abstract
OBJECTIVE: To evaluate the effect of protocol adherence on length of stay (LOS) and recovery-specific outcomes after colectomy. BACKGROUND: Enhanced recovery protocols (ERPs) may decrease postoperative morbidity and LOS; however, the effect of overall protocol adherence remains unclear. METHODS: Using American College of Surgeons' National Surgical Quality Improvement Program colectomy data (July 2014-December 2015) and 13 novel ERP variables, propensity scores were constructed for low (0-5), moderate (6-9), and high adherence (10-13 components). Prolonged LOS (>75th percentile, uncomplicated cases) was modeled with multivariable logistic regression with robust standard errors, adjusted for hospital-level clustering and propensity score. Secondary recovery-specific outcomes were modeled with negative binomial regression. Subgroup analysis was conducted on uncomplicated cases. RESULTS: Among 8139 elective colectomies at 113 hospitals, LOS increased with decreasing adherence (4.3 days [SD 3.3] high adherence vs 7.8 [SD 6.8] low adherence; P < 0.0001). High adherence was associated with fewer complications, including postoperative ileus, compared with moderate (P < 0.0001) and low adherence (P < 0.0001). High-adherence patients achieved recovery milestones earlier (vs low adherence), with return of bowel function at 1.9 (vs 3.7) days, tolerance of diet at 2.4 (vs 5.4) days, and oral pain control at 2.7 (vs 5.0) days (P < 0.0001). Risk-adjusted odds of prolonged LOS were significantly increased for low (odds ratio 2.7, 95% confidence interval 2.0-3.6) and moderate-adherence (odds ratio 1.7, 95% confidence interval 1.4-2.1) groups. In a negative binomial regression, time to recovery was 60% to 95% longer for low versus high adherence (P < 0.0001). CONCLUSIONS: In this large, multi-institutional North American data registry, high adherence to ERPs was associated with earlier recovery, decreased complications, and shorter LOS. ERPs can improve outcomes; however, benefits correlate with adherence.
OBJECTIVE: To evaluate the effect of protocol adherence on length of stay (LOS) and recovery-specific outcomes after colectomy. BACKGROUND: Enhanced recovery protocols (ERPs) may decrease postoperative morbidity and LOS; however, the effect of overall protocol adherence remains unclear. METHODS: Using American College of Surgeons' National Surgical Quality Improvement Program colectomy data (July 2014-December 2015) and 13 novel ERP variables, propensity scores were constructed for low (0-5), moderate (6-9), and high adherence (10-13 components). Prolonged LOS (>75th percentile, uncomplicated cases) was modeled with multivariable logistic regression with robust standard errors, adjusted for hospital-level clustering and propensity score. Secondary recovery-specific outcomes were modeled with negative binomial regression. Subgroup analysis was conducted on uncomplicated cases. RESULTS: Among 8139 elective colectomies at 113 hospitals, LOS increased with decreasing adherence (4.3 days [SD 3.3] high adherence vs 7.8 [SD 6.8] low adherence; P < 0.0001). High adherence was associated with fewer complications, including postoperative ileus, compared with moderate (P < 0.0001) and low adherence (P < 0.0001). High-adherence patients achieved recovery milestones earlier (vs low adherence), with return of bowel function at 1.9 (vs 3.7) days, tolerance of diet at 2.4 (vs 5.4) days, and oral pain control at 2.7 (vs 5.0) days (P < 0.0001). Risk-adjusted odds of prolonged LOS were significantly increased for low (odds ratio 2.7, 95% confidence interval 2.0-3.6) and moderate-adherence (odds ratio 1.7, 95% confidence interval 1.4-2.1) groups. In a negative binomial regression, time to recovery was 60% to 95% longer for low versus high adherence (P < 0.0001). CONCLUSIONS: In this large, multi-institutional North American data registry, high adherence to ERPs was associated with earlier recovery, decreased complications, and shorter LOS. ERPs can improve outcomes; however, benefits correlate with adherence.
Authors: Makena Pook; Hiba Elhaj; Charbel El Kefraoui; Saba Balvardi; Nicolo Pecorelli; Lawrence Lee; Liane S Feldman; Julio F Fiore Journal: Surg Endosc Date: 2022-02-25 Impact factor: 4.584
Authors: Nicolò Pecorelli; Saba Balvardi; A Sender Liberman; Patrick Charlebois; Barry Stein; Franco Carli; Liane S Feldman; Julio F Fiore Journal: Surg Endosc Date: 2019-01-30 Impact factor: 4.584
Authors: Jason B Liu; Andrea L Pusic; Bruce L Hall; Robert E Glasgow; Clifford Y Ko; Larissa K Temple Journal: J Gastrointest Surg Date: 2018-10-29 Impact factor: 3.452
Authors: Ana Sofia Ore; Matthew A Shear; Fong W Liu; John L Dalrymple; Christopher S Awtrey; Leslie Garrett; Hannah Stack-Dunnbier; Michele R Hacker; Katharine McKinley Esselen Journal: Int J Gynecol Cancer Date: 2019-11-25 Impact factor: 3.437
Authors: Rony Takchi; Heidy Cos; Gregory A Williams; Cheryl Woolsey; Chet W Hammill; Ryan C Fields; Steven M Strasberg; William G Hawkins; Dominic E Sanford Journal: HPB (Oxford) Date: 2021-06-16 Impact factor: 3.842