Michael Rera1, Céline Vallot2, Christel Lefrançois3. 1. Unité de Biologie Fonctionnelle et Adaptative (BFA) UMR8251 - CNRS - Université Diderot, Sorbonne Paris Cité. 2. Translational Department 'Dynamics of epigenetic alterations in breast cancer' UMR3244, Institut Curie, Paris. 3. LIENSs UMR7266, CNRS-Université La Rochelle, La Rochelle, France.
Abstract
PURPOSE OF REVIEW: Over the past 5 years, many articles were published concerning the prediction of high risk of mortality in apparently healthy adults, echoing the first description in 2011 of the Smurf phenotype, a harbinger of natural death in drosophila. RECENT FINDINGS: These recent findings suggest that the end-of-life is molecularly and physiologically highly stereotyped, evolutionarily conserved and predictable. SUMMARY: Taken altogether, these results from independent teams using multiple organisms including humans draw the lines of future directions in ageing research. The ability to identify and study individuals about to die of natural causes with no apparent diseases is a game-changer in this field. In addition, the public health applications are potentially of tremendous impact in our ageing societies and raise important ethical questions.
PURPOSE OF REVIEW: Over the past 5 years, many articles were published concerning the prediction of high risk of mortality in apparently healthy adults, echoing the first description in 2011 of the Smurf phenotype, a harbinger of natural death in drosophila. RECENT FINDINGS: These recent findings suggest that the end-of-life is molecularly and physiologically highly stereotyped, evolutionarily conserved and predictable. SUMMARY: Taken altogether, these results from independent teams using multiple organisms including humans draw the lines of future directions in ageing research. The ability to identify and study individuals about to die of natural causes with no apparent diseases is a game-changer in this field. In addition, the public health applications are potentially of tremendous impact in our ageing societies and raise important ethical questions.
Authors: Jason N Pitt; Nolan L Strait; Elena M Vayndorf; Benjamin W Blue; Christina H Tran; Brendon E M Davis; Karen Huang; Brock J Johnson; Keong Mu Lim; Sophie Liu; Arash Nikjoo; Anuj Vaid; Judy Z Wu; Matt Kaeberlein Journal: Geroscience Date: 2019-11-14 Impact factor: 7.713
Authors: Marie Gaille; Marco Araneda; Clément Dubost; Clémence Guillermain; Sarah Kaakai; Elise Ricadat; Nicolas Todd; Michael Rera Journal: BMC Med Ethics Date: 2020-07-27 Impact factor: 2.652