Allison M Daurio1, Sean A Aston1, Melanie L Schwandt2, Mohammad O Bukhari1, Sofia Bouhlal1, Mehdi Farokhnia1, Mary R Lee1, Lorenzo Leggio1,3. 1. Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland. 2. Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland. 3. Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, Rhode Island.
Abstract
BACKGROUND: While the role of attention-deficit/hyperactivity disorder (ADHD) as a risk factor for developing alcohol use disorder (AUD) has been established, the underlying pathways connecting the two are still not fully understood. Overlapping constructs such as impulsivity may explain the increased risk for developing AUD in individuals with ADHD. METHODS: In this study, we assessed whether adult ADHD symptoms increase the odds of having a diagnosis of AUD. Furthermore, we tested whether facets of impulsivity explained the relationship between ADHD symptoms and alcohol dependence (AD) severity. RESULTS: In a logistic regression of 749 participants (464 = AD, 285 = controls), overall adult ADHD symptoms, and more specifically, symptoms of hyperactivity/restlessness and problems with self-concept, increased the odds of having a diagnosis of AD. Within the AD sample, we found that impulsivity mediated the relationship between adult ADHD symptoms and AD severity. In particular, negative and positive urgency meditated the relationship of overall adult ADHD symptoms, and symptoms of hyperactivity/restlessness and problems with self-concept with AD severity. CONCLUSIONS: These results highlight the importance of looking at cohorts of ADHD symptoms and facets of impulsivity to assess the risk of developing AUD. They also suggest potential avenues for intervention strategies in individuals with preexisting adult ADHD symptoms who are seeking treatment for AUD. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
BACKGROUND: While the role of attention-deficit/hyperactivity disorder (ADHD) as a risk factor for developing alcohol use disorder (AUD) has been established, the underlying pathways connecting the two are still not fully understood. Overlapping constructs such as impulsivity may explain the increased risk for developing AUD in individuals with ADHD. METHODS: In this study, we assessed whether adult ADHD symptoms increase the odds of having a diagnosis of AUD. Furthermore, we tested whether facets of impulsivity explained the relationship between ADHD symptoms and alcohol dependence (AD) severity. RESULTS: In a logistic regression of 749 participants (464 = AD, 285 = controls), overall adult ADHD symptoms, and more specifically, symptoms of hyperactivity/restlessness and problems with self-concept, increased the odds of having a diagnosis of AD. Within the AD sample, we found that impulsivity mediated the relationship between adult ADHD symptoms and AD severity. In particular, negative and positive urgency meditated the relationship of overall adult ADHD symptoms, and symptoms of hyperactivity/restlessness and problems with self-concept with AD severity. CONCLUSIONS: These results highlight the importance of looking at cohorts of ADHD symptoms and facets of impulsivity to assess the risk of developing AUD. They also suggest potential avenues for intervention strategies in individuals with preexisting adult ADHD symptoms who are seeking treatment for AUD. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.
Entities:
Keywords:
Alcohol Use Disorder; Attention-Deficit/Hyperactivity Disorder; Impulsivity
Authors: Duneesha De Alwis; Arpana Agrawal; Angela M Reiersen; John N Constantino; Anjali Henders; Nicholas G Martin; Michael T Lynskey Journal: J Stud Alcohol Drugs Date: 2014-03 Impact factor: 2.582
Authors: Soyoung Q Park; Thorsten Kahnt; Anne Beck; Michael X Cohen; Raymond J Dolan; Jana Wrase; Andreas Heinz Journal: J Neurosci Date: 2010-06-02 Impact factor: 6.167
Authors: Honghuang Lin; Fan Wang; Andrew J Rosato; Lindsay A Farrer; David C Henderson; Huiping Zhang Journal: Epigenomics Date: 2020-06-04 Impact factor: 4.778