Aya M Tabbalat1, Nigel Pereira2, Devon Klauck3, Clara Melhem3, Rony T Elias3, Zev Rosenwaks3. 1. Weill Cornell Medicine-Qatar, Doha, Qatar. 2. The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Ave., New York, NY, 10021, USA. nip9060@med.cornell.edu. 3. The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Ave., New York, NY, 10021, USA.
Abstract
PURPOSE: Recent studies have demonstrated that ethnicity can be an independent determinant of assisted reproductive technology (ART) outcomes. In this context, we investigate whether ART outcomes differ between Arabian Peninsula and Caucasian women. METHODS: This is a retrospective cohort study of women undergoing fresh intracytoplasmic sperm injection (ICSI)-embryo transfer (ET) cycles for male factor infertility. The study cohort was divided into 2 groups based on ethnicity-Arabian Peninsula or Caucasian. Ovarian reserve, ovarian response, and pregnancy outcomes were compared between the groups. A sub-analysis was performed between individual Arabian Peninsula nationalities for the same outcomes. A multiple linear regression model was used to assess the independent effect of ethnicity on ovarian response. RESULTS: Seven hundred sixty-three patients were included-217 (28.4%) Arabian Peninsula and 546 (71.6%) Caucasian. There was no difference in the mean age of the two groups; however, the former had a higher body mass index (28.5 ± 7.5 vs. 23.3 ± 5.7; P < 0.001). Although follicle stimulating hormone (FSH) levels and antral follicle counts (AFC) were within the normal range in both groups, Arabian Peninsula women had higher FSH levels (5.7 ± 2.5 vs. 4.9 ± 2.8; P = 0.001) and lower AFC (13.9 ± 4.7 vs. 16.5 ± 4.3; P < 0.001) when compared to Caucasian women. Women from the Arabian Peninsula also had a statistically lower number of mature oocytes retrieved (15.6 ± 6.8 vs. 14.1 ± 8.4; P = 0.01), despite requiring higher gonadotropin doses. Multiple linear regression reveled that Arabian Peninsula women had 2.5 (95% CI 2.1-3.9) less mature oocytes, even after controlling for confounders. A sub-analysis within the Arab cohort demonstrated that Qatari women had a higher yield of mature oocytes when compared to Emirati, Kuwaiti, and Saudi women. There was no difference in the rates of implantation, clinical pregnancy, or live birth when comparing individual Arabian Peninsula nationalities with each other or to Caucasians. CONCLUSIONS: Arabian Peninsula ethnicity is associated with lower ovarian reserve and ovarian response parameters in women undergoing their first ICSI-ET cycle.
PURPOSE: Recent studies have demonstrated that ethnicity can be an independent determinant of assisted reproductive technology (ART) outcomes. In this context, we investigate whether ART outcomes differ between Arabian Peninsula and Caucasian women. METHODS: This is a retrospective cohort study of women undergoing fresh intracytoplasmic sperm injection (ICSI)-embryo transfer (ET) cycles for male factor infertility. The study cohort was divided into 2 groups based on ethnicity-Arabian Peninsula or Caucasian. Ovarian reserve, ovarian response, and pregnancy outcomes were compared between the groups. A sub-analysis was performed between individual Arabian Peninsula nationalities for the same outcomes. A multiple linear regression model was used to assess the independent effect of ethnicity on ovarian response. RESULTS: Seven hundred sixty-three patients were included-217 (28.4%) Arabian Peninsula and 546 (71.6%) Caucasian. There was no difference in the mean age of the two groups; however, the former had a higher body mass index (28.5 ± 7.5 vs. 23.3 ± 5.7; P < 0.001). Although follicle stimulating hormone (FSH) levels and antral follicle counts (AFC) were within the normal range in both groups, Arabian Peninsula women had higher FSH levels (5.7 ± 2.5 vs. 4.9 ± 2.8; P = 0.001) and lower AFC (13.9 ± 4.7 vs. 16.5 ± 4.3; P < 0.001) when compared to Caucasian women. Women from the Arabian Peninsula also had a statistically lower number of mature oocytes retrieved (15.6 ± 6.8 vs. 14.1 ± 8.4; P = 0.01), despite requiring higher gonadotropin doses. Multiple linear regression reveled that Arabian Peninsula women had 2.5 (95% CI 2.1-3.9) less mature oocytes, even after controlling for confounders. A sub-analysis within the Arab cohort demonstrated that Qatari women had a higher yield of mature oocytes when compared to Emirati, Kuwaiti, and Saudi women. There was no difference in the rates of implantation, clinical pregnancy, or live birth when comparing individual Arabian Peninsula nationalities with each other or to Caucasians. CONCLUSIONS: Arabian Peninsula ethnicity is associated with lower ovarian reserve and ovarian response parameters in women undergoing their first ICSI-ET cycle.
Authors: Barbara Luke; Morton B Brown; Judy E Stern; Stacey A Missmer; Victor Y Fujimoto; Richard Leach Journal: Fertil Steril Date: 2011-01-26 Impact factor: 7.329
Authors: Ragaa Mansour; Osamu Ishihara; G David Adamson; Silke Dyer; Jacques de Mouzon; Karl Gosta Nygren; Elizabeth Sullivan; Fernando Zegers-Hochschild Journal: Hum Reprod Date: 2014-05-02 Impact factor: 6.918
Authors: Victor Y Fujimoto; Barbara Luke; Morton B Brown; Tarun Jain; Alicia Armstrong; David A Grainger; Mark D Hornstein Journal: Fertil Steril Date: 2008-12-10 Impact factor: 7.329
Authors: Maya N Mascarenhas; Seth R Flaxman; Ties Boerma; Sheryl Vanderpoel; Gretchen A Stevens Journal: PLoS Med Date: 2012-12-18 Impact factor: 11.069
Authors: Ana Arnanz; Neelke De Munck; Ibrahim El Khatib; Aşina Bayram; Andrea Abdala; Laura Melado; Barbara Lawrenz; Carol Coughlan; Alberto Pacheco; Juan A Garcia-Velasco; Human M Fatemi Journal: Front Endocrinol (Lausanne) Date: 2021-01-25 Impact factor: 5.555
Authors: Laura Melado; Raquel Vitorino; Carol Coughlan; Leyla Depret Bixio; Ana Arnanz; Ibrahim Elkhatib; Neelke De Munck; Human M Fatemi; Barbara Lawrenz Journal: Front Endocrinol (Lausanne) Date: 2021-10-21 Impact factor: 5.555