Grace Neville1, Fiona Martyn2, Mark Kilbane3, Mairead O'Riordan4, Mary Wingfield5, Malachi McKenna6, Fionnuala M McAuliffe7. 1. National Maternity Hospital, Dublin, Ireland. 2. Merrion Fertility Clinic, National Maternity Hospital, Dublin, Ireland. 3. St Vincent's University Hospital, Dublin, Ireland. 4. University College Cork, Cork, Ireland. 5. National Maternity Hospital, Dublin, Ireland; Merrion Fertility Clinic, National Maternity Hospital, Dublin, Ireland; UCD Obstetrics and Gynaecology, School of Medicine, University College Dublin, Dublin, Ireland. 6. St Vincent's University Hospital, Dublin, Ireland; UCD School of Medicine, University College Dublin, Ireland. 7. National Maternity Hospital, Dublin, Ireland; UCD Obstetrics and Gynaecology, School of Medicine, University College Dublin, Dublin, Ireland. Electronic address: fionnuala.mcauliffe@ucd.ie.
Abstract
OBJECTIVE: To assess the vitamin D status of men and women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), and to investigate associations between vitamin D status and fertility variables. METHODS: A cross-sectional prospective study was undertaken of men and women attending a fertility clinic in Ireland for IVF/ICSI between January and March 2014. Vitamin D status was determined by measurement of serum 25-hydroxyvitamin D (25(OH)D). Questionnaires examined knowledge and practices concerning vitamin D. Fertility variables and pregnancy outcomes were assessed in relation to vitamin D status. RESULTS: Overall, 73 men and 64 women provided blood samples. Among men, no correlation was found between 25(OH)D and total motility (ρ=0.069, P=0.562), progressive motility (ρ=0.066, P=0.576), count (ρ=0.001, P=0.996), or morphology (ρ=-0.034, P=0.774) of sperm. Additionally, there was no association between 25(OH)D and ongoing pregnancy rates (P=0.158). There was no difference in 25(OH)D between men with and without male factor subfertility issues (P=0.856). Among women, there was no significant correlation between 25(OH)D and anti-Müllerian hormone (P=0.629) or number of collected (P=0.198) and fertilized oocytes (P=0.136). There was no difference in 25(OH)D between women with and without ongoing pregnancy (P=0.222). CONCLUSION: No correlation was found between fertility variables or pregnancy outcomes and male or female vitamin D status.
OBJECTIVE: To assess the vitamin D status of men and women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), and to investigate associations between vitamin D status and fertility variables. METHODS: A cross-sectional prospective study was undertaken of men and women attending a fertility clinic in Ireland for IVF/ICSI between January and March 2014. Vitamin D status was determined by measurement of serum 25-hydroxyvitamin D (25(OH)D). Questionnaires examined knowledge and practices concerning vitamin D. Fertility variables and pregnancy outcomes were assessed in relation to vitamin D status. RESULTS: Overall, 73 men and 64 women provided blood samples. Among men, no correlation was found between 25(OH)D and total motility (ρ=0.069, P=0.562), progressive motility (ρ=0.066, P=0.576), count (ρ=0.001, P=0.996), or morphology (ρ=-0.034, P=0.774) of sperm. Additionally, there was no association between 25(OH)D and ongoing pregnancy rates (P=0.158). There was no difference in 25(OH)D between men with and without male factor subfertility issues (P=0.856). Among women, there was no significant correlation between 25(OH)D and anti-Müllerian hormone (P=0.629) or number of collected (P=0.198) and fertilized oocytes (P=0.136). There was no difference in 25(OH)D between women with and without ongoing pregnancy (P=0.222). CONCLUSION: No correlation was found between fertility variables or pregnancy outcomes and male or female vitamin D status.
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