Literature DB >> 2906325

Regional localization of the autosomal dominant polycystic kidney disease locus.

S T Reeders1, T Keith, P Green, G G Germino, N J Barton, O J Lehmann, V A Brown, P Phipps, J Morgan, J C Bear.   

Abstract

The localization of the autosomal dominant polycystic kidney disease locus (PKD1) within an array of anonymous polymorphic DNA sequences on chromosome 16 band p13 was determined by multipoint mapping. Nine polymorphic DNA markers, including two hypervariable sequences, were used to study 19 PKD1 and 21 reference families. PKD1 was found to lie proximal to the 3' and 5' hypervariable regions of alpha-globin and distal to the anonymous sequence CRI-0327. Somatic cell hybrid mapping places PKD1 within the region 16p13.11-16pter. The availability of an array of linked markers which bracket the PKD1 locus provides a framework for further attempts to identify the PKD1 gene and offers an improved method of presymptomatic diagnosis of the disease.

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Year:  1988        PMID： 2906325     DOI： 10.1016/0888-7543(88)90146-2

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  19 in total

1.  Construction of a map of chromosome 16 by using radiation hybrids.

Authors:  I Ceccherini; G Romeo; S Lawrence; M H Breuning; P C Harris; H Himmelbauer; A M Frischauf; G R Sutherland; G G Germino; S T Reeders
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

2.  Defining DNA diagnostic tests appropriate or standard clinical care.

Authors:  R V Lebo; G Cunningham; M J Simons; L J Shapiro
Journal:  Am J Hum Genet       Date:  1990-09       Impact factor: 11.025

3.  Genetic linkage map of 46 DNA markers on human chromosome 16.

Authors:  T P Keith; P Green; S T Reeders; V A Brown; P Phipps; A Bricker; K Falls; K S Rediker; J A Powers; C Hogan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

4.  Recombination or heterogeneity: is there a second locus for adult polycystic kidney disease?

Authors:  R G Elles; A P Read; K A Hodgkinson; A Watters; R Harris
Journal:  J Med Genet       Date:  1990-07       Impact factor: 6.318

5.  Construction of the physical map for three loci in chromosome band 13q14: comparison to the genetic map.

Authors:  M J Higgins; C Turmel; J Noolandi; P E Neumann; M Lalande
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

6.  Map of 16 polymorphic loci on the short arm of chromosome 16 close to the polycystic kidney disease gene (PKD1).

Authors:  M H Breuning; F G Snijdewint; H Brunner; A Verwest; J W Ijdo; J J Saris; J G Dauwerse; L Blonden; T Keith; D F Callen
Journal:  J Med Genet       Date:  1990-10       Impact factor: 6.318

7.  Saturating the region of the polycystic kidney disease gene with NotI linking clones.

Authors:  H Himmelbauer; G G Germino; I Ceccherini; G Romeo; S T Reeders; A M Frischauf
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025

8.  Probe, VK5B, is located in the same interval as the autosomal dominant adult polycystic kidney disease locus, PKD1.

Authors:  V J Hyland; G K Suthers; K Friend; R N MacKinnon; D F Callen; M H Breuning; T Keith; V A Brown; P Phipps; G R Sutherland
Journal:  Hum Genet       Date:  1990-02       Impact factor: 4.132

9.  Diagnosis of adult polycystic kidney disease by genetic markers and ultrasonographic imaging in a voluntary family register.

Authors:  R G Elles; K A Hodgkinson; N P Mallick; D J O'Donoghue; A P Read; S Rimmer; E A Watters; R Harris
Journal:  J Med Genet       Date:  1994-02       Impact factor: 6.318

10.  Identification of a locus which shows no genetic recombination with the autosomal dominant polycystic kidney disease gene on chromosome 16.

Authors:  G G Germino; N J Barton; J Lamb; D R Higgs; P Harris; G H Xiao; G Scherer; Y Nakamura; S T Reeders
Journal:  Am J Hum Genet       Date:  1990-05       Impact factor: 11.025
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