Literature DB >> 29057309

Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation.

Samuel Sidi1,2, Lisa Bouchier-Hayes3,4.   

Abstract

Despite being frequently mutated or deregulated in acute myeloid leukemia (AML) and many other cancers, the mechanisms by which nucleophosmin (NPM1) regulates oncogenesis remain elusive. We found that NPM1 plays a direct and conserved role in DNA damage-induced assembly of the PIDDosome complex, the activating platform for caspase-2. This function is carried in the nucleolus and is essential for caspase-2-mediated apoptosis in response to a variety of DNA injuries.

Entities:  

Keywords:  Apoptosis; DNA damage; NPM1; PIDD; PIDDosome; RAIDD; caspase-2; nucleolus

Year:  2017        PMID： 29057309      PMCID： PMC5644479          DOI： 10.1080/23723556.2017.1348325

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.

Authors:  Antoine Tinel; Jürg Tschopp
Journal:  Science       Date:  2004-04-08       Impact factor: 47.728

Review 2.  Nucleophosmin and cancer.

Authors:  Silvia Grisendi; Cristina Mecucci; Brunangelo Falini; Pier Paolo Pandolfi
Journal:  Nat Rev Cancer       Date:  2006-07       Impact factor: 60.716

3.  An Inhibitor of PIDDosome Formation.

Authors:  Ruth Thompson; Richa B Shah; Peter H Liu; Yogesh K Gupta; Kiyohiro Ando; Aneel K Aggarwal; Samuel Sidi
Journal:  Mol Cell       Date:  2015-04-30       Impact factor: 17.970

4.  Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

Authors:  Brunangelo Falini; Cristina Mecucci; Enrico Tiacci; Myriam Alcalay; Roberto Rosati; Laura Pasqualucci; Roberta La Starza; Daniela Diverio; Emanuela Colombo; Antonella Santucci; Barbara Bigerna; Roberta Pacini; Alessandra Pucciarini; Arcangelo Liso; Marco Vignetti; Paola Fazi; Natalia Meani; Valentina Pettirossi; Giuseppe Saglio; Franco Mandelli; Francesco Lo-Coco; Pier-Giuseppe Pelicci; Massimo F Martelli
Journal:  N Engl J Med       Date:  2005-01-20       Impact factor: 91.245

5.  Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.

Authors:  Antoine Tinel; Sophie Janssens; Saskia Lippens; Solange Cuenin; Emmanuelle Logette; Bastienne Jaccard; Manfredo Quadroni; Jürg Tschopp
Journal:  EMBO J       Date:  2006-12-07       Impact factor: 11.598

6.  Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14.

Authors:  Xudong Chen; Yue Wang; Yu-Zen Chen; Brian L Harry; Akihisa Nakagawa; Eui-Seung Lee; Hongyan Guo; Ding Xue
Journal:  Nat Struct Mol Biol       Date:  2016-10-10       Impact factor: 15.369

7.  Characterization of cytoplasmic caspase-2 activation by induced proximity.

Authors:  Lisa Bouchier-Hayes; Andrew Oberst; Gavin P McStay; Samuel Connell; Stephen W G Tait; Christopher P Dillon; Jonathan M Flanagan; Helen M Beere; Douglas R Green
Journal:  Mol Cell       Date:  2009-09-24       Impact factor: 17.970

8.  Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

Authors:  Samuel Sidi; Takaomi Sanda; Richard D Kennedy; Andreas T Hagen; Cicely A Jette; Raymond Hoffmans; Jennifer Pascual; Shintaro Imamura; Shuji Kishi; James F Amatruda; John P Kanki; Douglas R Green; Alan A D'Andrea; A Thomas Look
Journal:  Cell       Date:  2008-05-30       Impact factor: 41.582

9.  PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.

Authors:  Kiyohiro Ando; Jennifer L Kernan; Peter H Liu; Takaomi Sanda; Emmanuelle Logette; Jurg Tschopp; A Thomas Look; Jianlong Wang; Lisa Bouchier-Hayes; Samuel Sidi
Journal:  Mol Cell       Date:  2012-07-30       Impact factor: 17.970

10.  NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.

Authors:  Kiyohiro Ando; Melissa J Parsons; Richa B Shah; Chloé I Charendoff; Sheré L Paris; Peter H Liu; Sara R Fassio; Brittany A Rohrman; Ruth Thompson; Andrew Oberst; Samuel Sidi; Lisa Bouchier-Hayes
Journal:  J Cell Biol       Date:  2017-04-21       Impact factor: 10.539
  10 in total
  1 in total

1.  Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia.

Authors:  Petra Hååg; Magnus Olsson; Jeremy Forsberg; Marita Lagergren Lindberg; Bo Stenerlöw; Dali Zong; Lena Kanter; Rolf Lewensohn; Kristina Viktorsson; Boris Zhivotovsky; Leif Stenke
Journal:  Cell Death Discov       Date:  2022-06-11
  1 in total

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