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Literature DB >> 16794633

Nucleophosmin and cancer.

Silvia Grisendi¹, Cristina Mecucci, Brunangelo Falini, Pier Paolo Pandolfi.

Abstract

NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions. Therefore, NPM can contribute to oncogenesis through many mechanisms. The aim of this review is to analyse the role of NPM in cancer, and examine how deregulated NPM activity (either gain or loss of function) can contribute to tumorigenesis.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16794633 DOI： 10.1038/nrc1885

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

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Cited

310 in total

1. Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription.

Authors: Z Li; S R Hann
Journal: Oncogene Date: 2012-06-04 Impact factor: 9.867

2. Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

Authors: Heiko Dückert; Verena Pries; Vivek Khedkar; Sascha Menninger; Hanna Bruss; Alexander W Bird; Zoltan Maliga; Andreas Brockmeyer; Petra Janning; Anthony Hyman; Stefan Grimme; Markus Schürmann; Hans Preut; Katja Hübel; Slava Ziegler; Kamal Kumar; Herbert Waldmann
Journal: Nat Chem Biol Date: 2011-12-25 Impact factor: 15.040

3. A plasma membrane wound proteome: reversible externalization of intracellular proteins following reparable mechanical damage.

Authors: Ronald L Mellgren
Journal: J Biol Chem Date: 2010-09-01 Impact factor: 5.157

Review 4. Nucleophosmin and human cancer.

Authors: Mi Jung Lim; Xin Wei Wang
Journal: Cancer Detect Prev Date: 2006-11-17

5. New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.

Authors: Younghwa Chun; Byoungwoo Park; Wansoo Koh; Sunhee Lee; Yeongmi Cheon; Raehyung Kim; Lihua Che; Soojin Lee
Journal: J Biol Chem Date: 2011-10-14 Impact factor: 5.157

Review 6. Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer.

Authors: Meng-Feng Tsai; Chi-Chung Wang; Jeremy Jw Chen
Journal: World J Clin Oncol Date: 2014-12-10

Nucleophosmin and cancer.

1. Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription.

2. Natural product-inspired cascade synthesis yields modulators of centrosome integrity.

3. A plasma membrane wound proteome: reversible externalization of intracellular proteins following reparable mechanical damage.

Review 4. Nucleophosmin and human cancer.

5. New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.

Review 6. Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer.

Review 7. Somatic Engineering of Oncogenic Chromosomal Rearrangements: A Perspective.

Review 8. Nuclear microenvironment in cancer diagnosis and treatment.

9. The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.

10. Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization.