Literature DB >> 29057307

JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.

Maithili P Dalvi1, Elisabeth D Martinez1.   

Abstract

Resistance to standard taxane-platin chemotherapy and tumor relapse are a major challenge in the treatment of non-small cell lung cancers (NSCLC). Our recent study identified JumonjiC demethylase inhibitors as a highly potent therapeutic strategy for targeting chemoresistant tumors and for preventing the emergence of drug-tolerant clones from taxane-platin treated NSCLCs.

Entities:  

Keywords:  Drug resistance; JmjC demethylases; Jumonji inhibitors; KDM; Non-small cell lung cancer; Standard chemotherapy; Taxane-platin

Year:  2017        PMID： 29057307      PMCID： PMC5644475          DOI： 10.1080/23723556.2017.1345352

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

Review 1.  Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.

Authors:  Juan Bayo; Maithili P Dalvi; Elisabeth D Martinez
Journal:  Future Med Chem       Date:  2015-10-29       Impact factor: 3.808

2.  Chemotherapy resistance and oncogene expression in non-small cell lung cancer.

Authors:  Thomas A d'Amato; Rodney J Landreneau; William Ricketts; Weidong Huang; Ricardo Parker; Eugene Mechetner; Ing-Ru Yu; James D Luketich
Journal:  J Thorac Cardiovasc Surg       Date:  2007-01-09       Impact factor: 5.209

3.  Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

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Journal:  Cell Stem Cell       Date:  2016-12-15       Impact factor: 24.633

4.  Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Authors:  Maithili P Dalvi; Lei Wang; Rui Zhong; Rahul K Kollipara; Hyunsil Park; Juan Bayo; Paul Yenerall; Yunyun Zhou; Brenda C Timmons; Jaime Rodriguez-Canales; Carmen Behrens; Barbara Mino; Pamela Villalobos; Edwin R Parra; Milind Suraokar; Apar Pataer; Stephen G Swisher; Neda Kalhor; Natarajan V Bhanu; Benjamin A Garcia; John V Heymach; Kevin Coombes; Yang Xie; Luc Girard; Adi F Gazdar; Ralf Kittler; Ignacio I Wistuba; John D Minna; Elisabeth D Martinez
Journal:  Cell Rep       Date:  2017-05-23       Impact factor: 9.423

5.  A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.

Authors:  Sreenath V Sharma; Diana Y Lee; Bihua Li; Margaret P Quinlan; Fumiyuki Takahashi; Shyamala Maheswaran; Ultan McDermott; Nancy Azizian; Lee Zou; Michael A Fischbach; Kwok-Kin Wong; Kathleyn Brandstetter; Ben Wittner; Sridhar Ramaswamy; Marie Classon; Jeff Settleman
Journal:  Cell       Date:  2010-04-02       Impact factor: 41.582

6.  Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells.

Authors:  Alexander Roesch; Adina Vultur; Ivan Bogeski; Huan Wang; Katharina M Zimmermann; David Speicher; Christina Körbel; Matthias W Laschke; Phyllis A Gimotty; Stephan E Philipp; Elmar Krause; Sylvie Pätzold; Jessie Villanueva; Clemens Krepler; Mizuho Fukunaga-Kalabis; Markus Hoth; Boris C Bastian; Thomas Vogt; Meenhard Herlyn
Journal:  Cancer Cell       Date:  2013-06-10       Impact factor: 31.743

7.  An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.

Authors:  Maia Vinogradova; Victor S Gehling; Amy Gustafson; Shilpi Arora; Charles A Tindell; Catherine Wilson; Kaylyn E Williamson; Gulfem D Guler; Pranoti Gangurde; Wanda Manieri; Jennifer Busby; E Megan Flynn; Fei Lan; Hyo-Jin Kim; Shobu Odate; Andrea G Cochran; Yichin Liu; Matthew Wongchenko; Yibin Yang; Tommy K Cheung; Tobias M Maile; Ted Lau; Michael Costa; Ganapati V Hegde; Erica Jackson; Robert Pitti; David Arnott; Christopher Bailey; Steve Bellon; Richard T Cummings; Brian K Albrecht; Jean-Christophe Harmange; James R Kiefer; Patrick Trojer; Marie Classon
Journal:  Nat Chem Biol       Date:  2016-05-23       Impact factor: 15.040

8.  A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.

Authors:  Lei Wang; Jianjun Chang; Diana Varghese; Michael Dellinger; Subodh Kumar; Anne M Best; Julio Ruiz; Richard Bruick; Samuel Peña-Llopis; Junjie Xu; David J Babinski; Doug E Frantz; Rolf A Brekken; Amy M Quinn; Anton Simeonov; Johnny Easmon; Elisabeth D Martinez
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  8 in total

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