Literature DB >> 29057303

RRM2B: An oxygen-requiring protein with a role in hypoxia.

Iosifina P Foskolou1, Ester M Hammond1.   

Abstract

How tumor cells adapt and survive under hypoxia significantly impacts patient prognosis. We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen availability by switching small subunits from RRM2 to RRM2B. This property of RNR is essential for hypoxic cell viability and therefore contributes to the most aggressive and therapy-resistant fraction of tumors.

Entities:  

Keywords:  Hypoxia; Replication stress; Ribonucleotide reductase

Year:  2017        PMID： 29057303      PMCID： PMC5644472          DOI： 10.1080/23723556.2017.1335272

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Ribonucleotide reductases.

Authors:  Pär Nordlund; Peter Reichard
Journal:  Annu Rev Biochem       Date:  2006       Impact factor: 23.643

Review 2.  Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.

Authors:  Y Aye; M Li; M J C Long; R S Weiss
Journal:  Oncogene       Date:  2014-06-09       Impact factor: 9.867

3.  A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.

Authors:  H Tanaka; H Arakawa; T Yamaguchi; K Shiraishi; S Fukuda; K Matsui; Y Takei; Y Nakamura
Journal:  Nature       Date:  2000-03-02       Impact factor: 49.962

4.  Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

Authors:  Vassilis G Gorgoulis; Leandros-Vassilios F Vassiliou; Panagiotis Karakaidos; Panayotis Zacharatos; Athanassios Kotsinas; Triantafillos Liloglou; Monica Venere; Richard A Ditullio; Nikolaos G Kastrinakis; Brynn Levy; Dimitris Kletsas; Akihiro Yoneta; Meenhard Herlyn; Christos Kittas; Thanos D Halazonetis
Journal:  Nature       Date:  2005-04-14       Impact factor: 49.962

Review 5.  Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.

Authors:  M Höckel; P Vaupel
Journal:  J Natl Cancer Inst       Date:  2001-02-21       Impact factor: 13.506

6.  Nucleotide deficiency promotes genomic instability in early stages of cancer development.

Authors:  Assaf C Bester; Maayan Roniger; Yifat S Oren; Michael M Im; Dan Sarni; Malka Chaoat; Aaron Bensimon; Gideon Zamir; Donna S Shewach; Batsheva Kerem
Journal:  Cell       Date:  2011-04-29       Impact factor: 41.582

7.  Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

Authors:  Isabel M Pires; Zuzana Bencokova; Manuela Milani; Lisa K Folkes; Ji-Liang Li; Mike R Stratford; Adrian L Harris; Ester M Hammond
Journal:  Cancer Res       Date:  2010-01-26       Impact factor: 12.701

8.  Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.

Authors:  Iosifina P Foskolou; Christian Jorgensen; Katarzyna B Leszczynska; Monica M Olcina; Hanna Tarhonskaya; Bauke Haisma; Vincenzo D'Angiolella; William K Myers; Carmen Domene; Emily Flashman; Ester M Hammond
Journal:  Mol Cell       Date:  2017-04-13       Impact factor: 17.970

9.  Studies of ribonucleotide reductase in crucian carp-an oxygen dependent enzyme in an anoxia tolerant vertebrate.

Authors:  Guro K Sandvik; Ane B Tomter; Jonas Bergan; Giorgio Zoppellaro; Anne-Laure Barra; Asmund K Røhr; Matthias Kolberg; Stian Ellefsen; K Kristoffer Andersson; Göran E Nilsson
Journal:  PLoS One       Date:  2012-08-14       Impact factor: 3.240

10.  Replication stress and chromatin context link ATM activation to a role in DNA replication.

Authors:  Monica M Olcina; Iosifina P Foskolou; Selvakumar Anbalagan; Joana M Senra; Isabel M Pires; Yanyan Jiang; Anderson J Ryan; Ester M Hammond
Journal:  Mol Cell       Date:  2013-11-21       Impact factor: 17.970
  10 in total
  3 in total

1.  RRM2B Is Frequently Amplified Across Multiple Tumor Types: Implications for DNA Repair, Cellular Survival, and Cancer Therapy.

Authors:  Waleed Iqbal; Elena V Demidova; Samantha Serrao; Taha ValizadehAslani; Gail Rosen; Sanjeevani Arora
Journal:  Front Genet       Date:  2021-03-12       Impact factor: 4.599

2.  Targeting matrix metallopeptidase 2 by hydroxyurea selectively kills acute myeloid mixed-lineage leukemia.

Authors:  Ruiheng Wang; Shufeng Xie; Shouhai Zhu; Yong Sun; Bowen Shi; Dan Li; Ting Kang; Yuanli Wang; Zhenshu Xu; Han Liu
Journal:  Cell Death Discov       Date:  2022-04-08

Review 3.  Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer.

Authors:  Deborah Nazareth; Mathew Jk Jones; Brian Gabrielli
Journal:  Cancers (Basel)       Date:  2019-09-06       Impact factor: 6.639
  3 in total

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