Literature DB >> 29057300

Targeting ATR/CHK1 pathway in acute myeloid leukemia to overcome chemoresistance.

Laure David1,2,3, Stéphane Manenti1,2,3, Christian Récher2,3,4, Jean-Sébastien Hoffmann1,2,3, Christine Didier1,2,3.   

Abstract

Resistance of acute myeloid leukemia to current therapies leads to frequent relapses. Identification of molecular mechanisms involved in chemoresistance constitutes a key challenge to define new therapeutic concepts. Here, we show that the ATR/CHK1 pathway, essential in maintaining genomic stability, is involved in resistance and proliferation characteristics of leukemic cells.

Entities:  

Keywords:  ATR and CHK1 kinases; Acute Myeloid Leukemia; Chemoresistance; DNA replicative stress

Year:  2017        PMID： 29057300      PMCID： PMC5644474          DOI： 10.1080/23723556.2017.1289293

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication.

Authors:  Cai Guo; Akiko Kumagai; Katharina Schlacher; Anna Shevchenko; Andrej Shevchenko; William G Dunphy
Journal:  Mol Cell       Date:  2014-12-31       Impact factor: 17.970

2.  CHK1 as a therapeutic target to bypass chemoresistance in AML.

Authors:  Laure David; Anne Fernandez-Vidal; Sarah Bertoli; Srdana Grgurevic; Benoît Lepage; Dominique Deshaies; Naïs Prade; Maëlle Cartel; Clément Larrue; Jean-Emmanuel Sarry; Eric Delabesse; Christophe Cazaux; Christine Didier; Christian Récher; Stéphane Manenti; Jean-Sébastien Hoffmann
Journal:  Sci Signal       Date:  2016-09-13       Impact factor: 8.192

3.  Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.

Authors:  Cindy Cavelier; Christine Didier; Naïs Prade; Véronique Mansat-De Mas; Stéphane Manenti; Christian Recher; Cécile Demur; Bernard Ducommun
Journal:  Cancer Res       Date:  2009-10-20       Impact factor: 12.701

4.  Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.

Authors:  Midori Shimada; Hiroyuki Niida; Doaa H Zineldeen; Hideaki Tagami; Masafumi Tanaka; Hiroyuki Saito; Makoto Nakanishi
Journal:  Cell       Date:  2008-01-25       Impact factor: 41.582

Review 5.  An oncogene-induced DNA damage model for cancer development.

Authors:  Thanos D Halazonetis; Vassilis G Gorgoulis; Jiri Bartek
Journal:  Science       Date:  2008-03-07       Impact factor: 47.728

Review 6.  Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs.

Authors:  Luis I Toledo; Matilde Murga; Oscar Fernandez-Capetillo
Journal:  Mol Oncol       Date:  2011-07-28       Impact factor: 6.603

7.  Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia.

Authors:  Tyrone Ryba; Dana Battaglia; Bill H Chang; James W Shirley; Quinton Buckley; Benjamin D Pope; Meenakshi Devidas; Brian J Druker; David M Gilbert
Journal:  Genome Res       Date:  2012-05-24       Impact factor: 9.043

8.  An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation.

Authors:  Andres J López-Contreras; Paula Gutierrez-Martinez; Julia Specks; Sara Rodrigo-Perez; Oscar Fernandez-Capetillo
Journal:  J Exp Med       Date:  2012-02-27       Impact factor: 14.307

9.  A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors.

Authors:  Sergio Ruiz; Cristina Mayor-Ruiz; Vanesa Lafarga; Matilde Murga; Maria Vega-Sendino; Sagrario Ortega; Oscar Fernandez-Capetillo
Journal:  Mol Cell       Date:  2016-04-07       Impact factor: 17.970

10.  Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

Authors:  Isabel Morgado-Palacin; Amanda Day; Matilde Murga; Vanesa Lafarga; Marta Elena Anton; Anthony Tubbs; Hua Tang Chen; Aysegul Ergan; Rhonda Anderson; Avinash Bhandoola; Kurt G Pike; Bernard Barlaam; Elaine Cadogan; Xi Wang; Andrew J Pierce; Chad Hubbard; Scott A Armstrong; André Nussenzweig; Oscar Fernandez-Capetillo
Journal:  Sci Signal       Date:  2016-09-13       Impact factor: 8.192
  10 in total
  1 in total

Review 1.  Partners in crime: POPX2 phosphatase and its interacting proteins in cancer.

Authors:  Pu Rum Kim; Songjing Zhang; Muhammad Bakhait Rahmat; Cheng-Gee Koh
Journal:  Cell Death Dis       Date:  2020-10-09       Impact factor: 8.469
  1 in total

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