Vivian E Strong1, Ashley Russo1, Sam S Yoon1, Murray F Brennan1, Daniel G Coit1, Chao-Hui Zheng2, Ping Li3, Chang-Ming Huang4. 1. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. 3. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. pingli811002@163.com. 4. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. hcmlr2002@163.com.
Abstract
BACKGROUND: This study aimed to compare the clinicopathologic characteristics and stage-specific prognosis of young patients with gastric cancer (GC) after curative resection (R0) in the United States and China. METHODS: Data were collected on young patients (age ≤40 years) undergoing R0 resection at one U.S. (n = 79) and one Chinese (n = 257) institution. Patient, surgical, and pathologic variables and stage-specific survival rates were compared. Factors associated with 5-year disease-specific survival (DSS) were determined via multivariate analysis. RESULTS: Tumor location was most often proximal in U.S. patients and distal in Chinese patients. The Chinese patients had more advanced-stage tumors, with a greater number of positive lymph nodes identified. Preoperative chemotherapy was administered more often in the United States. The 5-year overall survival (p = 0.07) and DSS (p = 0.07) did not differ statistically between the U.S. and Chinese cohorts. Among the patients with early GC receiving surgery alone, DSS did not differ significantly between the two cohorts (p = 0.44). Among the patients with advanced GC, DSS was comparable between the U.S. patients receiving preoperative chemotherapy plus surgery and the Chinese patients receiving surgery plus postoperative chemotherapy (p = 0.85). Lauren classification, depth of invasion, number of metastatic lymph nodes, and type of gastrectomy, but not country, were independent predictors of DSS. CONCLUSIONS: Tumor features and therapeutic strategies among young patients with GC differ between the United States and China. Survival is comparable between young patients with advanced GC receiving preoperative chemotherapy plus surgery in the United States and those receiving surgery plus postoperative chemotherapy in China, suggesting that the outcomes for young patients with GC are stage dependent but not country specific.
BACKGROUND: This study aimed to compare the clinicopathologic characteristics and stage-specific prognosis of young patients with gastric cancer (GC) after curative resection (R0) in the United States and China. METHODS: Data were collected on young patients (age ≤40 years) undergoing R0 resection at one U.S. (n = 79) and one Chinese (n = 257) institution. Patient, surgical, and pathologic variables and stage-specific survival rates were compared. Factors associated with 5-year disease-specific survival (DSS) were determined via multivariate analysis. RESULTS: Tumor location was most often proximal in U.S. patients and distal in Chinese patients. The Chinese patients had more advanced-stage tumors, with a greater number of positive lymph nodes identified. Preoperative chemotherapy was administered more often in the United States. The 5-year overall survival (p = 0.07) and DSS (p = 0.07) did not differ statistically between the U.S. and Chinese cohorts. Among the patients with early GC receiving surgery alone, DSS did not differ significantly between the two cohorts (p = 0.44). Among the patients with advanced GC, DSS was comparable between the U.S. patients receiving preoperative chemotherapy plus surgery and the Chinese patients receiving surgery plus postoperative chemotherapy (p = 0.85). Lauren classification, depth of invasion, number of metastatic lymph nodes, and type of gastrectomy, but not country, were independent predictors of DSS. CONCLUSIONS: Tumor features and therapeutic strategies among young patients with GC differ between the United States and China. Survival is comparable between young patients with advanced GC receiving preoperative chemotherapy plus surgery in the United States and those receiving surgery plus postoperative chemotherapy in China, suggesting that the outcomes for young patients with GC are stage dependent but not country specific.
Authors: Jun Zou; Wan Qin; Lin Yang; Lulu Wang; Yu Wang; Jianfeng Shen; Wei Xiong; Shiying Yu; Shumei Song; Jaffer A Ajani; Shiaw-Yih Lin; Gordon B Mills; Xianglin Yuan; Jianying Chen; Guang Peng Journal: Am J Cancer Res Date: 2020-11-01 Impact factor: 6.166
Authors: Elvira L Vos; Masaya Nakauchi; Mithat Gönen; Jason A Castellanos; Alberto Biondi; Daniel G Coit; Johan L Dikken; Domenico D'Ugo; Henk Hartgrink; Ping Li; Makoto Nishimura; Mark Schattner; Kyo Young Song; Laura H Tang; Ichiro Uyama; Santosha Vardhana; Rob H A Verhoeven; Bas P L Wijnhoven; Vivian E Strong Journal: Ann Surg Date: 2021-12-14 Impact factor: 13.787