M Dorsi1, A Giuseppi1, F Lesage2, J Stirnemann3,4, L De Saint Blanquat3, M Nicloux1, Z Assaf1, N Khen Dunlop3,5, E Kermorvant-Duchemin1,3, J-F Magny1,3, Y Ville3,4, A Lapillonne1,3. 1. Department of Neonatal Intensive Care, APHP Necker Hospital, Paris, France. 2. Department of Pediatric Intensive Care, APHP Necker Hospital, Paris, France. 3. Paris Descartes University (EA 7328), Sorbonne Paris Cite, France. 4. Department of Obstetrics, APHP Necker Hospital, Paris, France. 5. Department of Pediatric Surgery, APHP Necker Hospital, Paris, France.
Abstract
OBJECTIVES: Congenital chylothorax is a rare disease and prognostic factors are key element in properly informing parents. This study aimed at determining the prenatal factors associated with neonatal survival in a cohort of liveborn infants with congenital chylothorax. STUDY DESIGN: Observational monocentric cohort study including all liveborn neonates consecutively admitted for congenital chylothorax. RESULTS: Neonatal mortality was 32% (16/50). Prematurity (or birth weight), persistence of hydrops at birth and the absence of thoracoamniotic shunt procedure were significantly associated with mortality, whereas prenatal diagnosis of pleural effusion, side of pleural effusion, hydrops fetalis and amniodrainage were not. In case of prenatal diagnosis of hydrops fetalis, the reversal in utero of hydrops fetalis was significantly associated with survival (P=0.001). In case of thoracoamniotic shunting, the interval between thoracoamniotic shunting intervention and delivery was significantly longer for patients who survived (P=0.03). CONCLUSIONS: Thoracoamniotic shunting and reversal of hydrops significantly improves survival, whereas prematurity worsened outcome of liveborn infants with congenital chylothorax. Our data also suggest that the interval between thoracoamniotic shunting and birth appears to be crucial; the longer the interval, the more likely is the reversal of antenatal hydrops and neonatal survival.
OBJECTIVES: Congenital chylothorax is a rare disease and prognostic factors are key element in properly informing parents. This study aimed at determining the prenatal factors associated with neonatal survival in a cohort of liveborn infants with congenital chylothorax. STUDY DESIGN: Observational monocentric cohort study including all liveborn neonates consecutively admitted for congenital chylothorax. RESULTS: Neonatal mortality was 32% (16/50). Prematurity (or birth weight), persistence of hydrops at birth and the absence of thoracoamniotic shunt procedure were significantly associated with mortality, whereas prenatal diagnosis of pleural effusion, side of pleural effusion, hydrops fetalis and amniodrainage were not. In case of prenatal diagnosis of hydrops fetalis, the reversal in utero of hydrops fetalis was significantly associated with survival (P=0.001). In case of thoracoamniotic shunting, the interval between thoracoamniotic shunting intervention and delivery was significantly longer for patients who survived (P=0.03). CONCLUSIONS: Thoracoamniotic shunting and reversal of hydrops significantly improves survival, whereas prematurity worsened outcome of liveborn infants with congenital chylothorax. Our data also suggest that the interval between thoracoamniotic shunting and birth appears to be crucial; the longer the interval, the more likely is the reversal of antenatal hydrops and neonatal survival.
Authors: D Diomande; K Husseini; V Meau-Petit; C Dupont; O Picone; P Boileau Journal: Arch Dis Child Fetal Neonatal Ed Date: 2008-07 Impact factor: 5.747
Authors: Joseph T Church; Alexis G Antunez; Ashley Dean; Niki Matusko; Kristopher B Deatrick; Mohammad A Attar; Samir K Gadepalli Journal: J Pediatr Surg Date: 2017-03-16 Impact factor: 2.545
Authors: Y Yinon; S Grisaru-Granovsky; V Chaddha; R Windrim; P G R Seaward; E N Kelly; O Beresovska; G Ryan Journal: Ultrasound Obstet Gynecol Date: 2010-07 Impact factor: 7.299