Literature DB >> 29040032

Interventions and Outcomes in Patients with Infectious Pseudomonas scleritis: A 10-Year Perspective.

Sumayya Ahmad1, Michelle Lopez2, Marwan Attala2, Anat Galor2, Natalie A Stanciu2, Darlene Miller2, Leejee Suh3, Thomas Albini2, Victor L Perez2, Carol L Karp2, Janet L Davis2, Eduardo Alfonso2, Richard K Forster2, Guillermo Amescua2.   

Abstract

Purpose: To identify interventional factors associated with improved visual results and faster time to resolution for patients with Pseudomonas scleritis.
Methods: Retrospective study analyzing inciting factors, therapeutic modalities, and outcomes of patients with Pseudomonas scleritis.
Results: A total of 24 patients were analyzed; 22 were treated as outpatients. All had resolution of infection and 58% (n = 14) maintained ≥20/200 vision. Medical therapy included topical and oral antibiotics; seven received additional subconjunctival injections; two were admitted for IV antibiotics. Patients presenting with ≥20/200 vision were more likely to maintain this level of vision (n = 8, 80%) compared to those presenting with severe vision loss (n = 5, 36%) (p = 0.04). A similar proportion of patients who received (n = 8, 61%) and did not receive (n = 5, 39%) oral steroids achieved 20/200 vision or better once infection resolved, p = 1.0. Conclusions: Pseudomonas scleritis can be successfully managed in the outpatient setting. Oral steroids do not appear harmful in the treatment of this disease.

Entities:  

Keywords:  Infectious scleritis; review; steroids

Year:  2017        PMID: 29040032      PMCID: PMC6240493          DOI: 10.1080/09273948.2017.1372484

Source DB:  PubMed          Journal:  Ocul Immunol Inflamm        ISSN: 0927-3948            Impact factor:   3.070


  38 in total

1.  Antimicrobial activity of antibiotic-treated amniotic membrane: An in vitro study.

Authors:  Rita Mencucci; Ugo Menchini; Rosanna Dei
Journal:  Cornea       Date:  2006-05       Impact factor: 2.651

2.  Early addition of topical corticosteroids in the treatment of bacterial keratitis.

Authors:  Kathryn J Ray; Muthiah Srinivasan; Jeena Mascarenhas; Revathi Rajaraman; Meenakshi Ravindran; David V Glidden; Catherine E Oldenburg; Catherine Q Sun; Michael E Zegans; Stephen D McLeod; Nisha R Acharya; Thomas M Lietman
Journal:  JAMA Ophthalmol       Date:  2014-06       Impact factor: 7.389

3.  Drug reservoir function of human amniotic membrane.

Authors:  Miklós D Resch; Béla E Resch; Eszter Csizmazia; László Imre; János Németh; Piroska Szabó-Révész; Erzsébet Csányi
Journal:  J Ocul Pharmacol Ther       Date:  2011-06-24       Impact factor: 2.671

4.  Pseudomonas aeruginosa keratitis: outcomes and response to corticosteroid treatment.

Authors:  Aileen Sy; Muthiah Srinivasan; Jeena Mascarenhas; Prajna Lalitha; Revathi Rajaraman; Meenakshi Ravindran; Catherine E Oldenburg; Kathryn J Ray; David Glidden; Michael E Zegans; Stephen D McLeod; Thomas M Lietman; Nisha R Acharya
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-01-25       Impact factor: 4.799

5.  Management and outcome of microbial anterior scleritis.

Authors:  Matthew A Cunningham; Jamie K Alexander; Alice Y Matoba; Dan B Jones; Kirk R Wilhemus
Journal:  Cornea       Date:  2011-09       Impact factor: 2.651

6.  The treatment of Pseudomonas keratoscleritis after pterygium excision.

Authors:  S C Huang; H C Lai; I C Lai
Journal:  Cornea       Date:  1999-09       Impact factor: 2.651

7.  Oral ciprofloxacin compared with conventional intravenous treatment for Pseudomonas aeruginosa infection in adults with cystic fibrosis.

Authors:  M E Hodson; C M Roberts; R J Butland; M J Smith; J C Batten
Journal:  Lancet       Date:  1987-01-31       Impact factor: 79.321

8.  Microbial scleritis-experience from a developing country.

Authors:  V Jain; P Garg; S Sharma
Journal:  Eye (Lond)       Date:  2008-01-25       Impact factor: 3.775

9.  Emerging moxifloxacin resistance in Pseudomonas aeruginosa keratitis isolates in South India.

Authors:  Catherine E Oldenburg; Prajna Lalitha; Muthiah Srinivasan; Revathi Rajaraman; Meenakshi Ravindran; Jeena Mascarenhas; Durga S Borkar; Kathryn J Ray; Michael E Zegans; Stephen D McLeod; Travis C Porco; Thomas M Lietman; Nisha R Acharya
Journal:  Ophthalmic Epidemiol       Date:  2013-05-10       Impact factor: 1.648

10.  Infectious scleritis after retinal surgery.

Authors:  Ryan M Rich; William E Smiddy; Janet L Davis
Journal:  Am J Ophthalmol       Date:  2008-02-01       Impact factor: 5.258

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  5 in total

1.  Pseudomonas aeruginosa Scleritis following Pterygium Surgery with Mitomycin C or Beta Irradiation: Three-Case Report.

Authors:  Winai Chaidaroon; Somsanguan Ausayakhun; Napaporn Tananuvat; Phit Upaphong; Kittipong Thabsuwan
Journal:  Case Rep Ophthalmol Med       Date:  2022-05-05

Review 2.  Scleritis: Differentiating infectious from non-infectious entities.

Authors:  Somasheila I Murthy; Swapnali Sabhapandit; S Balamurugan; Pranesh Subramaniam; Maite Sainz-de-la-Maza; Manisha Agarwal; Carlos Parvesio
Journal:  Indian J Ophthalmol       Date:  2020-09       Impact factor: 1.848

3.  Umbilical amnion and amniotic membrane transplantation for infectious scleritis and scleral melt: A case series.

Authors:  Zeba A Syed; Christopher J Rapuano
Journal:  Am J Ophthalmol Case Rep       Date:  2021-01-23

4.  Reply to editor comment on Alternaria chartarum sclerokeratouveitis: A new fungus cause.

Authors:  Luz Elena Concha Del Rio; Carolina Ramirez-Dominguez; Virginia Vanzzini-Zago; Lourdes Arellanes-Garcia
Journal:  Taiwan J Ophthalmol       Date:  2021-10-27

5.  Alternaria chartarum sclerokeratouveitis: A new fungus cause.

Authors:  Luz Elena Concha Del Río; Carolina Ramirez-Dominguez; Virginia Vanzzini-Zago; Lourdes Arellanes-Garcia
Journal:  Taiwan J Ophthalmol       Date:  2020-04-27
  5 in total

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