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Literature DB >> 29039143

CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis.

Yanlan Huang¹, Yong Li¹, Bin Wei¹, Weifeng Wu², Xingcui Gao¹.

Abstract

The cluster of differentiation protein complex, CD80/CD86, regulates Th1/Th2 differentiation in autoimmune disease. In order to establish the effects of CD80/CD86 on Th17 cell differentiation in acute viral myocarditis (VMC), we infected C57BL/6 mice with Coxsackie virus B3 (CVB3) and examined the effects of the treatment with anti-CD80/CD86 monoclonal antibodies (mAbs) on Th17 cell differentiation in vivo. The effects of anti-CD80/CD86 mAbs on Th17 cell differentiation were further evaluated in vitro. The treatment with anti-CD80 mAb induced marked suppression of Th17 cell differentiation and ROR-γt mRNA expression, whereas anti-CD86 mAb alone had no effect, both in vivo and in vitro. Our finding that CD80 regulates Th17 differentiation supports the potential utility of anti-CD80 mAb as an effective new immunotherapeutic target in acute VMC.

Entities: Disease Gene Species

Keywords: CD80; CD86; Th17 cells; differentiation; viral myocarditis

Mesh：

Substances：

Year: 2018 PMID： 29039143 DOI： 10.1007/s10753-017-0681-7

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

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