Cherry Kim1,2, Sang Min Lee3, Jooae Choe1, Eun Jin Chae1, Kyung-Hyun Do1, Joon Beom Seo1. 1. Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Centre, 88 Olympic-ro 43 gil, Songpa-Gu, Seoul, 05505, Korea. 2. Department of Radiology, Ansan Hospital, Korea University College of Medicine, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, 15355, Gyeonggi, Korea. 3. Department of Radiology and the Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Centre, 88 Olympic-ro 43 gil, Songpa-Gu, Seoul, 05505, Korea. sangmin.lee.md@gmail.com.
Abstract
OBJECTIVES: To assess the volume doubling time (VDT) of lung cancers in IIP compared with COPD. METHODS: A total of 61 patients (32 with IIP and 29 with COPD) were identified. A radiologist performed three-dimensional manual segmentation for lung cancers. VDTs were calculated and compared between two groups. Logistic regression was performed to identify factors associated with rapid tumour growth (VDT < 90 days). RESULTS: The median VDT of lung cancers in IIP (78.2 days) was significantly shorter than that in COPD (126.1 days; p=0.004). Squamous cell carcinoma (SqCC) was the most frequent subtype, followed by small cell lung cancer (SCLC) in IIP. In COPD, SqCC was the most frequent subtype, followed by adenocarcinoma. Rapid tumour growth was observed in 20 cancers from IIP, and in nine cancers from COPD (p=0.021). SCLC was significantly correlated with rapid tumour growth (p=0.038). Multivariate analysis revealed that the presence of IIP was the single independent predictor of rapid tumour growth (p = 0.016; odds ratio, 3.7). CONCLUSIONS: Lung cancers in IIP showed more rapid growth, with median VDT < 90 days. Therefore, a shorter follow-up interval (<90 days) may be necessary when CT surveillance is considered in IIP patients with suspected lung cancer. KEY POINTS: • The median VDTs of lung cancers in IIP was 78.2 days. • Rapid tumour growth occurred more frequently in IIP than in COPD. • IIP was the single independent predictor of rapid tumour growth. • Shorter CT follow-up interval may be necessary in IIP with suspicious nodules.
OBJECTIVES: To assess the volume doubling time (VDT) of lung cancers in IIP compared with COPD. METHODS: A total of 61 patients (32 with IIP and 29 with COPD) were identified. A radiologist performed three-dimensional manual segmentation for lung cancers. VDTs were calculated and compared between two groups. Logistic regression was performed to identify factors associated with rapid tumour growth (VDT < 90 days). RESULTS: The median VDT of lung cancers in IIP (78.2 days) was significantly shorter than that in COPD (126.1 days; p=0.004). Squamous cell carcinoma (SqCC) was the most frequent subtype, followed by small cell lung cancer (SCLC) in IIP. In COPD, SqCC was the most frequent subtype, followed by adenocarcinoma. Rapid tumour growth was observed in 20 cancers from IIP, and in nine cancers from COPD (p=0.021). SCLC was significantly correlated with rapid tumour growth (p=0.038). Multivariate analysis revealed that the presence of IIP was the single independent predictor of rapid tumour growth (p = 0.016; odds ratio, 3.7). CONCLUSIONS:Lung cancers in IIP showed more rapid growth, with median VDT < 90 days. Therefore, a shorter follow-up interval (<90 days) may be necessary when CT surveillance is considered in IIP patients with suspected lung cancer. KEY POINTS: • The median VDTs of lung cancers in IIP was 78.2 days. • Rapid tumour growth occurred more frequently in IIP than in COPD. • IIP was the single independent predictor of rapid tumour growth. • Shorter CT follow-up interval may be necessary in IIP with suspicious nodules.
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