BACKGROUND: Obesity is a common chronic disease, and elevated serum uric acid has been suggested to be associated with obesity. However, whether the elevation is casual or a consequence of obesity remains unclear. We performed the study to investigate the longitudinal association between serum uric acid levels and obesity. METHODS: A total of 4411 initially obesity-free subjects were followed up for 9 years. The subjects were divided into groups according to the serum uric acid quartile. Univariable and multivariable Cox regression models were used to analyze the risk factors for the development of obesity. RESULTS: Of the 4411 subjects, 1272 (28.8%) subjects developed obesity over 9 years of follow-up. The cumulative incidence of obesity was 21.7%, 26.4%, 31.0%, and 36.4% in quartile 1, 2, 3 and 4, respectively (p for trend < 0.001). Cox regression analyses indicated that serum uric acid levels were independently and positively associated with the risk of incident obesity. CONCLUSIONS: Our longitudinal study demonstrated that high serum uric acid levels increase the risk of obesity.
BACKGROUND:Obesity is a common chronic disease, and elevated serum uric acid has been suggested to be associated with obesity. However, whether the elevation is casual or a consequence of obesity remains unclear. We performed the study to investigate the longitudinal association between serum uric acid levels and obesity. METHODS: A total of 4411 initially obesity-free subjects were followed up for 9 years. The subjects were divided into groups according to the serum uric acid quartile. Univariable and multivariable Cox regression models were used to analyze the risk factors for the development of obesity. RESULTS: Of the 4411 subjects, 1272 (28.8%) subjects developed obesity over 9 years of follow-up. The cumulative incidence of obesity was 21.7%, 26.4%, 31.0%, and 36.4% in quartile 1, 2, 3 and 4, respectively (p for trend < 0.001). Cox regression analyses indicated that serum uric acid levels were independently and positively associated with the risk of incident obesity. CONCLUSIONS: Our longitudinal study demonstrated that high serum uric acid levels increase the risk of obesity.
Authors: Thaís da Silva Ferreira; Julia Freitas Rodrigues Fernandes; Luciene da Silva Araújo; Lívia de Paula Nogueira; Priscila Mansur Leal; Vanessa Parada Antunes; Maria de Lourdes Guimarães Rodrigues; Debora Cristina Torres Valença; Sergio Emanuel Kaiser; Márcia Regina Simas Torres Klein Journal: Arq Bras Cardiol Date: 2018-10-11 Impact factor: 2.000