Literature DB >> 29034942

Guanidinium-based "molecular glues" for modulation of biomolecular functions.

Rina Mogaki1, P K Hashim, Kou Okuro, Takuzo Aida.   

Abstract

Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, "molecular glues" that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strategies for developing adhesive motifs for biomolecules based on multivalent interactions. We highlight a guanidinium ion-based salt-bridge as a key interaction for adhesion to biomolecules and discuss the application of molecular glues for manipulation of biomolecular assemblies, drug delivery systems, and modulation of biomolecular functions.

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Year:  2017        PMID： 29034942     DOI： 10.1039/c7cs00647k

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  11 in total

1.  Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes.

Authors:  Santiago Correa; Natalie Boehnke; Elad Deiss-Yehiely; Paula T Hammond
Journal:  ACS Nano       Date:  2019-04-18       Impact factor: 15.881

2.  Dynamic Covalent Polymers for Biomedical Applications.

Authors:  Yan Zhang; Yunchuan Qi; Sébastien Ulrich; Mihail Barboiu; Olof Ramström
Journal:  Mater Chem Front       Date:  2019-12-03

Review 3.  Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation.

Authors:  Sisi Chen; Lei Zhang; Quan Yuan; Jie Tan
Journal:  Chem Res Chin Univ       Date:  2022-05-07       Impact factor: 2.726

4.  Electrostatic Conjugation of Nanoparticle Surfaces with Functional Peptide Motifs.

Authors:  Natalie Boehnke; Kate J Dolph; Valeria M Juarez; Julia M Lanoha; Paula T Hammond
Journal:  Bioconjug Chem       Date:  2020-08-11       Impact factor: 4.774

5.  Autocatalytic and oscillatory reaction networks that form guanidines and products of their cyclization.

Authors:  Alexander I Novichkov; Anton I Hanopolskyi; Xiaoming Miao; Linda J W Shimon; Yael Diskin-Posner; Sergey N Semenov
Journal:  Nat Commun       Date:  2021-05-20       Impact factor: 14.919

Review 6.  The Power of Assemblies at Interfaces: Nanosensor Platforms Based on Synthetic Receptor Membranes.

Authors:  Tsukuru Minamiki; Yuki Ichikawa; Ryoji Kurita
Journal:  Sensors (Basel)       Date:  2020-04-15       Impact factor: 3.576

7.  Guanidinylation of Chitooligosaccharides Involving Internal Cyclization of the Guanidino Group on the Reducing End and Effect of Guanidinylation on Protein Binding Ability.

Authors:  Hironori Izawa; Mizuki Kinai; Shinsuke Ifuku; Minoru Morimoto; Hiroyuki Saimoto
Journal:  Biomolecules       Date:  2019-07-05

8.  Enabling long-lived organic room temperature phosphorescence in polymers by subunit interlocking.

Authors:  Suzhi Cai; Huili Ma; Huifang Shi; He Wang; Xuan Wang; Leixin Xiao; Wenpeng Ye; Kaiwei Huang; Xudong Cao; Nan Gan; Chaoqun Ma; Mingxing Gu; Lulu Song; Hai Xu; Youtian Tao; Chunfeng Zhang; Wei Yao; Zhongfu An; Wei Huang
Journal:  Nat Commun       Date:  2019-09-18       Impact factor: 14.919

Review 9.  From Interaction to Function in DNA-Templated Supramolecular Self-Assemblies.

Authors:  Mathieu Surin; Sébastien Ulrich
Journal:  ChemistryOpen       Date:  2020-04-22       Impact factor: 2.911

10.  Enhanced Cellular Uptake in an Electrostatically Interacting Fucoidan-L-Arginine Fiber Complex.

Authors:  Vinothini Arunagiri; Hsieh-Chih Tsai; Haile Fentahun Darge; Endiries Yibru Hanurry; Chang Yi Lee; Juin-Yih Lai; Szu-Yuan Wu
Journal:  Polymers (Basel)       Date:  2021-05-29       Impact factor: 4.329
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