Xianwen Meng1, Qi Chen1, Peijing Zhang1, Ming Chen1. 1. Department of Bioinformatics; State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Abstract
SUMMARY: Circular RNAs (circRNAs), a novel class of endogenous RNAs, are widespread in eukaryotic cells. Emerging roles in diverse biological processes suggest that circRNA is a promising key player in RNA world. Most circRNAs are generated through back-splicing of pre-mRNAs, forming a covalently closed loop structure with no 5' caps or 3' polyadenylated tails. In addition, most circRNAs were not associated with translating ribosomes, therefore, circRNAs were deemed to be noncoding. However, the latest research findings revealed that some circRNAs could generate proteins in vivo, which expands the landscape of transcriptome and proteome. To gain insights into the new area of circRNA translation, we introduce an integrated tool capable of detecting circRNAs with protein-coding potential from high-throughput sequencing data. AVAILABILITY AND IMPLEMENTATION: CircPro is available at http://bis.zju.edu.cn/CircPro. CONTACT: mchen@zju.edu.cn. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
SUMMARY: Circular RNAs (circRNAs), a novel class of endogenous RNAs, are widespread in eukaryotic cells. Emerging roles in diverse biological processes suggest that circRNA is a promising key player in RNA world. Most circRNAs are generated through back-splicing of pre-mRNAs, forming a covalently closed loop structure with no 5' caps or 3' polyadenylated tails. In addition, most circRNAs were not associated with translating ribosomes, therefore, circRNAs were deemed to be noncoding. However, the latest research findings revealed that some circRNAs could generate proteins in vivo, which expands the landscape of transcriptome and proteome. To gain insights into the new area of circRNA translation, we introduce an integrated tool capable of detecting circRNAs with protein-coding potential from high-throughput sequencing data. AVAILABILITY AND IMPLEMENTATION: CircPro is available at http://bis.zju.edu.cn/CircPro. CONTACT: mchen@zju.edu.cn. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Authors: Zhifan Zuo; Tingsong Chen; Yue Zhang; Lei Han; Bo Liu; Bin Yang; Tao Han; Zhendong Zheng Journal: Am J Transl Res Date: 2021-12-15 Impact factor: 4.060
Authors: Clarissa P C Gomes; Antonio Salgado-Somoza; Esther E Creemers; Christoph Dieterich; Mitja Lustrek; Yvan Devaux Journal: Noncoding RNA Res Date: 2018-02-25