Literature DB >> 29024330

C-H Functionalisation for Hydrogen Isotope Exchange.

Jens Atzrodt1, Volker Derdau1, William J Kerr2, Marc Reid2.   

Abstract

The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demand a range of methods for their installation in an array of molecular architectures. In this Review, we describe recent advances in synthetic C-H functionalisation for hydrogen isotope exchange.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  C−H functionalization; catalysis; drug discovery; hydrogen isotope exchange

Year:  2018        PMID： 29024330     DOI： 10.1002/anie.201708903

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  38 in total

1.  Enabling Two-Electron Pathways with Iron and Cobalt: From Ligand Design to Catalytic Applications.

Authors:  Rebeca Arevalo; Paul J Chirik
Journal:  J Am Chem Soc       Date:  2019-05-28       Impact factor: 15.419

2.  Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C-H Bonds of Drug Molecules.

Authors:  Yejin Chang; Ahmet Yesilcimen; Min Cao; Yuyang Zhang; Bochao Zhang; Jessica Z Chan; Masayuki Wasa
Journal:  J Am Chem Soc       Date:  2019-09-09       Impact factor: 15.419

3.  B(C6F5)3-Catalyzed α-Deuteration of Bioactive Carbonyl Compounds with D2O.

Authors:  Yejin Chang; Tanner Myers; Masayuki Wasa
Journal:  Adv Synth Catal       Date:  2019-11-26       Impact factor: 5.837

4.  Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction.

Authors:  Zuyuan Shen; Shilei Zhang; Huihui Geng; Jiarui Wang; Xinyu Zhang; Anqi Zhou; Cheng Yao; Xiaobei Chen; Wei Wang
Journal:  Org Lett       Date:  2019-01-07       Impact factor: 6.005

5.  Direct Carbon Isotope Exchange through Decarboxylative Carboxylation.

Authors:  Cian Kingston; Michael A Wallace; Alban J Allentoff; Justine N deGruyter; Jason S Chen; Sharon X Gong; Samuel Bonacorsi; Phil S Baran
Journal:  J Am Chem Soc       Date:  2019-01-03       Impact factor: 15.419

6.  Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach.

Authors:  Yueteng Zhang; Peng Ji; Yue Dong; Yongyi Wei; Wei Wang
Journal:  ACS Catal       Date:  2020-01-23       Impact factor: 13.084

Review 7.  N-Heterocyclic Carbene Complexes in C-H Activation Reactions.

Authors:  Qun Zhao; Guangrong Meng; Steven P Nolan; Michal Szostak
Journal:  Chem Rev       Date:  2020-01-22       Impact factor: 60.622

8.  Formyl-selective deuteration of aldehydes with D2O via synergistic organic and photoredox catalysis.

Authors:  Jianyang Dong; Xiaochen Wang; Zhen Wang; Hongjian Song; Yuxiu Liu; Qingmin Wang
Journal:  Chem Sci       Date:  2019-12-04       Impact factor: 9.825

9.  Catalyst design in C-H activation: a case study in the use of binding free energies to rationalise intramolecular directing group selectivity in iridium catalysis.

Authors:  William J Kerr; Gary J Knox; Marc Reid; Tell Tuttle
Journal:  Chem Sci       Date:  2021-04-20       Impact factor: 9.825

10.  H/D exchange under mild conditions in arenes and unactivated alkanes with C6D6 and D2O using rigid, electron-rich iridium PCP pincer complexes.

Authors:  Joel D Smith; George Durrant; Daniel H Ess; Benjamin S Gelfand; Warren E Piers
Journal:  Chem Sci       Date:  2020-06-16       Impact factor: 9.825
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