I M A Traore1, T M Zohoncon1, O Ndo2, F W Djigma3, D Obiri-Yeboah4, T R Compaore1, S P Guigma1, A T Yonli1, G Traore5, P Ouedraogo6, C M R Ouedraogo7, Y Traore8, J Simpore6. 1. Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso. 2. Health District of Orodara, Burkina Faso. 3. Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso. 4. Department of Microbiology, School of Medical Sciences, University of Cape Coast, Ghana. 5. Obstetrician-gynecologist, Polyvalent Medical Ce nter-Health and Reproduction, Bobo, Burkina Faso. 6. Faculty of Medicine, University Saint Thomas d' Aquin, 06 BP 10212 Ouagadougou 01, Burkina Faso. 7. Obstetrician-gynecologist, UFR/SDS, University of Ouagadougou, 03 BP 7021 Ouagadougou 03,Yalgado Ouedraogo University Hospital (CHU/YO), 03 BP 7022, Burkina Faso. 8. Training and Research Unit in Life and Earth Science (UFR/SVT), University of Ouagadougou, Burkina Faso.
Abstract
BACKGROUND AND OBJECTIVE: Cervical cancer usually occurs several years after persistent infection with oncogenic or high-risk human papillomavirus. The objective of this study was to determine carriage of 14 genotypes of high-risk human papillomavirus among women at Orodara and then characterize the genotypes found in these women. MATERIALS AND METHODS: From June to July 2015, 120 women from the general population were recruited in the health district of Orodara. They voluntarily agreed to participate in the study. Endocervical samples were taken from these women prior to screening for precancerous lesions by visual inspection with acetic acid and lugol's iodine. Identification of high-risk human papillomavirus genotype was done using real-time PCR. RESULTS: High-risk human papillomavirus prevalence was 38.3% and the most common genotypes were HPV 52 (25.4%), HPV 33 (20.6%) and HPV 59 (11.1%). The HPV 66 was also identified with a prevalence of 9.5%. CONCLUSION: The HPV 16 and HPV 18 which are frequently associated with cancer worldwide were not found among the most frequent oncogenic HPV in women in Orodara.
BACKGROUND AND OBJECTIVE: Cervical cancer usually occurs several years after persistent infection with oncogenic or high-risk human papillomavirus. The objective of this study was to determine carriage of 14 genotypes of high-risk human papillomavirus among women at Orodara and then characterize the genotypes found in these women. MATERIALS AND METHODS: From June to July 2015, 120 women from the general population were recruited in the health district of Orodara. They voluntarily agreed to participate in the study. Endocervical samples were taken from these women prior to screening for precancerous lesions by visual inspection with acetic acid and lugol's iodine. Identification of high-risk human papillomavirus genotype was done using real-time PCR. RESULTS: High-risk human papillomavirus prevalence was 38.3% and the most common genotypes were HPV 52 (25.4%), HPV 33 (20.6%) and HPV 59 (11.1%). The HPV 66 was also identified with a prevalence of 9.5%. CONCLUSION: The HPV 16 and HPV 18 which are frequently associated with cancer worldwide were not found among the most frequent oncogenic HPV in women in Orodara.
Entities:
Keywords:
High-risk HPV; Western Burkina Faso; cervical cancer; cervix; genotypes; prevalence; real-time PCR; women
Authors: Amrei Krings; Priscilla Dunyo; Aleksandra Pesic; Saviour Tetteh; Benjamin Hansen; Isaac Gedzah; Comfort M Wormenor; Joseph E Amuah; Anna-Lisa Behnke; Daniela Höfler; Michael Pawlita; Andreas M Kaufmann Journal: PLoS One Date: 2019-06-27 Impact factor: 3.240
Authors: Akouélé P Kuassi-Kpede; Essolakina Dolou; Théodora M Zohoncon; Ina Marie Angèle Traore; Gnatoulma Katawa; R Alice Ouedraogo; Esther Mah Traore; Prosper Bado; T Clarisse Ouedraogo; Florencia Wendkuuni Djigma; Simplice Damintoti Karou; Jacques Simpore Journal: BMC Infect Dis Date: 2021-03-19 Impact factor: 3.090