Luis Emilio Pablo1,2, Maria Pilar Bambo3,4, Beatriz Cameo1,2, Blanca Ferrández1,2, Noemí Güerri1,2, Vicente Polo1,2, Jose Manuel Larrosa1,2, Javier Moreno-Montañés5, Elena Garcia-Martin1,2. 1. Ophthalmology Department, Miguel Servet University Hospital, C/Padre Arrupe, Consultas Externas de Oftalmología, 50009, Saragossa, Spain. 2. Aragon Institute for Health Research (IIS Aragón), University of Zaragoza, Saragossa, Spain. 3. Ophthalmology Department, Miguel Servet University Hospital, C/Padre Arrupe, Consultas Externas de Oftalmología, 50009, Saragossa, Spain. mpbamborubio@gmail.com. 4. Aragon Institute for Health Research (IIS Aragón), University of Zaragoza, Saragossa, Spain. mpbamborubio@gmail.com. 5. Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain.
Abstract
PURPOSE: To evaluate automatic peripapillary choroidal thickness (PPCT) measurements in a wide area around the optic disc and various established zones in primary open-angle glaucoma (POAG) patients and age- and sex-matched healthy controls using a new swept-source optical coherence tomography (SS-OCT) device. STUDY DESIGN: Single center cross-sectional observational study. METHODS: A total of 135 POAG patients and 86 healthy subjects were consecutively enrolled. An optic disc 6.0 × 6.0 mm three-dimensional scan OD was obtained using the SS-OCT Triton. A 26 × 26 cube-grid centered in the optic disc was generated to automatically measure choroidal thickness. Seven choroidal zones were established (superior temporal, central, and nasal; inferior temporal, central, and nasal, and the optic nerve head) and compared between healthy controls and POAG patients. RESULTS: PPCT was significantly thinner in the central superior, nasal superior, and nasal inferior zones of the POAG subjects. Choroidal thickness in the central superior zone was 124.61 ± 54.95 µm in POAG group vs 156.17 ± 80.89 µm in healthy controls (p = 0.029); in the nasal superior zone, 133.84 ± 58.89 µm in the POAG group vs 168.34 ± 73.45 µm in healthy controls (p = 0.012); and in the nasal inferior zone, 113.45 ± 49.93 µm in the POAG group vs 137.47 ± 65.96 µm in healthy controls (p = 0.049). CONCLUSION: Compared with healthy subjects, glaucoma patients present with peripapillary choroidal thinning, especially in the central superior, nasal superior, and nasal inferior zones. The new SS-OCT could be a useful tool to evaluate choroidal thinning, and it could be an additional support to facilitate glaucoma diagnosis.
PURPOSE: To evaluate automatic peripapillary choroidal thickness (PPCT) measurements in a wide area around the optic disc and various established zones in primary open-angle glaucoma (POAG) patients and age- and sex-matched healthy controls using a new swept-source optical coherence tomography (SS-OCT) device. STUDY DESIGN: Single center cross-sectional observational study. METHODS: A total of 135 POAG patients and 86 healthy subjects were consecutively enrolled. An optic disc 6.0 × 6.0 mm three-dimensional scan OD was obtained using the SS-OCT Triton. A 26 × 26 cube-grid centered in the optic disc was generated to automatically measure choroidal thickness. Seven choroidal zones were established (superior temporal, central, and nasal; inferior temporal, central, and nasal, and the optic nerve head) and compared between healthy controls and POAG patients. RESULTS: PPCT was significantly thinner in the central superior, nasal superior, and nasal inferior zones of the POAG subjects. Choroidal thickness in the central superior zone was 124.61 ± 54.95 µm in POAG group vs 156.17 ± 80.89 µm in healthy controls (p = 0.029); in the nasal superior zone, 133.84 ± 58.89 µm in the POAG group vs 168.34 ± 73.45 µm in healthy controls (p = 0.012); and in the nasal inferior zone, 113.45 ± 49.93 µm in the POAG group vs 137.47 ± 65.96 µm in healthy controls (p = 0.049). CONCLUSION: Compared with healthy subjects, glaucomapatients present with peripapillary choroidal thinning, especially in the central superior, nasal superior, and nasal inferior zones. The new SS-OCT could be a useful tool to evaluate choroidal thinning, and it could be an additional support to facilitate glaucoma diagnosis.
Authors: Jean-Claude Mwanza; Jessica T Hochberg; Michael R Banitt; William J Feuer; Donald L Budenz Journal: Invest Ophthalmol Vis Sci Date: 2011-05-18 Impact factor: 4.799