Literature DB >> 2901953

The structure of the human CD2 gene and its expression in transgenic mice.

G Lang1, D Wotton, M J Owen, W A Sewell, M H Brown, D Y Mason, M J Crumpton, D Kioussis.   

Abstract

We report the genomic organization of the human CD2 gene and its expression in transgenic mice. A 28.5 kb segment of DNA consisting of 4.5 kb 5' flanking sequences, 15 kb containing the gene's five exons and 9 kb of 3' flanking sequences can direct the expression of the CD2 gene only on thymocytes, circulating T cells and megakaryocytes of the transgenic mice. The expression of each copy of the human CD2 transgene appears to be as high as the endogenous mouse CD2 gene and as high as the expression on the surface of human T lymphocytes, independent of the site of integration and dependent on the copy number of genes that have integrated.

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Year:  1988        PMID： 2901953      PMCID： PMC457152          DOI： 10.1002/j.1460-2075.1988.tb02995.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  38 in total

1.  Transformation of mammalian cells with genes from procaryotes and eucaryotes.

Authors:  M Wigler; R Sweet; G K Sim; B Wold; A Pellicer; E Lacy; T Maniatis; S Silverstein; R Axel
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Calcium-dependent bacteriophage DNA infection.

Authors:  M Mandel; A Higa
Journal:  J Mol Biol       Date:  1970-10-14       Impact factor: 5.469

4.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

Review 5.  The differentiation and function of human T lymphocytes.

Authors:  E L Reinherz; S F Schlossman
Journal:  Cell       Date:  1980-04       Impact factor: 41.582

6.  Cell lineage heterogeneity in blast crisis of chronic myeloid leukaemia.

Authors:  P Bettelheim; D Lutz; O Majdic; E Paietta; O Haas; W Linkesch; E Neumann; K Lechner; W Knapp
Journal:  Br J Haematol       Date:  1985-03       Impact factor: 6.998

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Genetic transformation of mouse embryos by microinjection of purified DNA.

Authors:  J W Gordon; G A Scangos; D J Plotkin; J A Barbosa; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

Authors:  C Auffray; F Rougeon
Journal:  Eur J Biochem       Date:  1980-06

10.  Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.

Authors:  M Kamoun; P J Martin; J A Hansen; M A Brown; A W Siadak; R C Nowinski
Journal:  J Exp Med       Date:  1981-01-01       Impact factor: 14.307
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  52 in total

Review 1.  Artificial chromosome-based transgenes in the study of genome function.

Authors:  Jason D Heaney; Sarah K Bronson
Journal:  Mamm Genome       Date:  2006-08-04       Impact factor: 2.957

2.  Identification of cis sequences controlling efficient position-independent tissue-specific expression of human major histocompatibility complex class I genes in transgenic mice.

Authors:  J W Chamberlain; H A Vasavada; S Ganguly; S M Weissman
Journal:  Mol Cell Biol       Date:  1991-07       Impact factor: 4.272

Review 3.  Regulation of apoptosis in immune cells.

Authors:  J D Mountz; T Zhou; J Wu; W Wang; X Su; J Cheng
Journal:  J Clin Immunol       Date:  1995-01       Impact factor: 8.317

Review 4.  Recent advances in transgenic technology.

Authors:  E R Cameron
Journal:  Mol Biotechnol       Date:  1997-06       Impact factor: 2.695

5.  Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues.

Authors:  B D Ortiz; D Cado; V Chen; P W Diaz; A Winoto
Journal:  EMBO J       Date:  1997-08-15       Impact factor: 11.598

6.  Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48).

Authors:  R C Fisher; D A Thorley-Lawson
Journal:  Mol Cell Biol       Date:  1991-03       Impact factor: 4.272

7.  The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells.

Authors:  G G Grütz; K Bucher; I Lavenir; T Larson; R Larson; T H Rabbitts
Journal:  EMBO J       Date:  1998-08-17       Impact factor: 11.598

8.  Human CD4 produced in lymphoid cells of transgenic mice binds HIV gp120 and modifies the subsets of mouse T-cell populations.

Authors:  P Forte; A Aiuti; L Pozzi; F Citarella; A Fattorossi; G B Rossi; A Fantoni
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846

9.  Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice.

Authors:  C B Whitelaw; S Harris; M McClenaghan; J P Simons; A J Clark
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

Review 10.  Delivery of DNA into mammalian cells by receptor-mediated endocytosis and gene therapy.

Authors:  J Guy; D Drabek; M Antoniou
Journal:  Mol Biotechnol       Date:  1995-06       Impact factor: 2.695
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