Literature DB >> 2901925

Novel HLA class II-associated structural patterns in coeliac disease and type I diabetes.

N Fernandez1, G A Hitman, H Festenstein, L Garde, M Labeta, J A Walker-Smith, J A Sachs.   

Abstract

Cell membrane antigens were precipitated from EBV transformed cell lines by a monomorphic DR monoclonal antibody. Three mutually exclusive patterns with two glycoproteins (g25 and g28) that had not been previously identified, were observed. The first, g25+/g28- was found in all cell lines from 40 healthy individuals; a second, g25-/g28- was found in 4/7 coeliac and 2/4 IDDM patients and a third, g25+/g28+ was found in 3/7 coeliac and 1/4 IDDM patients. RFLP analysis with Class II alpha and beta chain probes and several restriction enzymes did not correlate with either of the disease associated patterns. Several possibilities regarding the identity and mode of action of the two polypeptides are described.

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Year:  1988        PMID： 2901925      PMCID： PMC1541555     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  16 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

Authors:  O Cohen-Haguenauer; E Robbins; C Massart; M Busson; I Deschamps; J Hors; J M Lalouel; J Dausset; D Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

3.  Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

Authors:  L M Kunkel; K D Smith; S H Boyer; D S Borgaonkar; S S Wachtel; O J Miller; W R Breg; H W Jones; J M Rary
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

4.  An antiviral T-cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short, DRw11, and DRw13 haplotypes.

Authors:  D Zeliszewski; G Sterkers; J Choppin; C Freidel; L Gebuhrer; H Betuel; J P Levy
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

5.  H-2-linked low-molecular weight polypeptide antigens assemble into an unusual macromolecular complex.

Authors:  J J Monaco; H O McDevitt
Journal:  Nature       Date:  1984 Jun 28-Jul 4       Impact factor: 49.962

6.  The invariant chains of mouse class II antigens: biochemical properties and molecular relationship.

Authors:  R Zecher; W Ballhausen; K Reske; D Linder; M Schlüter; S Stirm
Journal:  Eur J Immunol       Date:  1984-06       Impact factor: 5.532

7.  HLA class II alpha chain gene polymorphisms in patients with insulin-dependent diabetes mellitus, dermatitis herpetiformis, and celiac disease.

Authors:  G A Hitman; M J Niven; H Festenstein; P G Cassell; J Awad; J Walker-Smith; J N Leonard; L Fry; P Ciclitira; P Kumar
Journal:  J Clin Invest       Date:  1987-02       Impact factor: 14.808

8.  Demonstration of two distinct light chains in HLA-DR-associated antigens by two-dimensional gel electrophoresis.

Authors:  T A de Kretser; M J Crumpton; J G Bodmer; W F Bodmer
Journal:  Eur J Immunol       Date:  1982-03       Impact factor: 5.532

9.  Polymorphic restriction endonuclease sites linked to the HLA-DR alpha gene: localization and use as genetic markers of insulin-dependent diabetes.

Authors:  D Stetler; F C Grumet; H A Erlich
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

10.  HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals.

Authors:  D Owerbach; A Lernmark; P Platz; L P Ryder; L Rask; P A Peterson; J Ludvigsson
Journal:  Nature       Date:  1983-06-30       Impact factor: 49.962
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  1 in total

1.  Cell-surface expression of human histocompatibility leucocyte antigen (HLA) class II-associated invariant chain (CD74) does not always correlate with cell-surface expression of HLA class II molecules.

Authors:  K M Wilson; M O Labeta; G Pawelec; N Fernandez
Journal:  Immunology       Date:  1993-06       Impact factor: 7.397
  1 in total

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